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Melatonin promotes reduction in TNF levels and improves the lipid profile and insulin sensitivity in pinealectomized rats with periodontal disease

dc.contributor.authorSantos, Rodrigo Martins dos [UNESP]
dc.contributor.authorMarani, Fernando [UNESP]
dc.contributor.authorChiba, Fernando Yamamoto [UNESP]
dc.contributor.authorMattera, Maria Sara de Lima Coutinho [UNESP]
dc.contributor.authorTsosura, Thais Verônica Saori [UNESP]
dc.contributor.authorTessarin, Gestter Willian Lattari [UNESP]
dc.contributor.authorPereira, Renato Felipe [UNESP]
dc.contributor.authorBelardi, Bianca Elvira [UNESP]
dc.contributor.authorPinheiro, Beatriz Costa E Silva [UNESP]
dc.contributor.authorSumida, Doris Hissako [UNESP]
dc.contributor.institutionPrograma de Pós-graduação Multicêntrico em Ciências Fisiológicas-SBFis
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-06T16:00:43Z
dc.date.available2019-10-06T16:00:43Z
dc.date.issued2018-11-15
dc.description.abstractAim: This study aimed to investigate the effects of melatonin (ME) on insulin resistance (IR) and signaling (IS), proinflammatory cytokine levels, and lipid profiles in pinealectomyzed (PNX) rats with periodontal disease (PD). Main methods: One hundred and forty-four rats (age = 40 days) were distributed into 8 groups: 1) control (CN); 2) PD only; 3) PNX only; 4) PNX and PD (PNXPD); 5) CN treated with ME (CNM); 6) PD treated with ME (PDM); 7) PNX treated with ME(PNXM); 8) PNX and PD treated with ME(PNXPDM). The PNX groups were subjected to pinealectomy at 40 and at 60 days of age. The animals were then subjected to PD induction in the mandibular first molars. After PD induction, the ME replacement therapy (MERT-5 mg/kg body weight) was performed using water for 28 days. After this period, the plasma concentration of glucose, insulin, TNF, IL-6, triglycerides, total cholesterol, HDL-cholesterol, LDL-cholesterol, and VLDL-cholesterol and the HOMA-IR index were determined. Akt serine phosphorylation status in the white adipose tissue, gastrocnemius muscle, and rat liver were also evaluated. Key findings: PD, PNX, and PNXPD groups showed an increase in IR with elevated plasma levels of insulin and TNF compared to CN group. PNX and PNXPD groups presented alteration in lipid profile compared to CN group. MERT improved all of the analyzed parameters. No difference was observed in the IS among different groups. Significance: The results suggest that MERT efficiently prevents IR, improves lipid profile, and increases plasma levels of insulin and TNF in PD and PNX rats.en
dc.description.affiliationPrograma de Pós-graduação Multicêntrico em Ciências Fisiológicas-SBFis
dc.description.affiliationPreventive and Social Dentistry Post-Graduation Program School of Dentistry of Araçatuba São Paulo State University (UNESP)
dc.description.affiliationDepartment of Basic Sciences School of Dentistry of Araçatuba São Paulo State University (UNESP)
dc.description.affiliationInstitute of Biosciences of Botucatu São Paulo State University
dc.description.affiliationUnespPreventive and Social Dentistry Post-Graduation Program School of Dentistry of Araçatuba São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Basic Sciences School of Dentistry of Araçatuba São Paulo State University (UNESP)
dc.description.affiliationUnespInstitute of Biosciences of Botucatu São Paulo State University
dc.format.extent32-39
dc.identifierhttp://dx.doi.org/10.1016/j.lfs.2018.09.056
dc.identifier.citationLife Sciences, v. 213, p. 32-39.
dc.identifier.doi10.1016/j.lfs.2018.09.056
dc.identifier.issn1879-0631
dc.identifier.issn0024-3205
dc.identifier.scopus2-s2.0-85054849268
dc.identifier.urihttp://hdl.handle.net/11449/188206
dc.language.isoeng
dc.relation.ispartofLife Sciences
dc.rights.accessRightsAcesso abertopt
dc.sourceScopus
dc.subjectCholesterol
dc.subjectInsulin resistance
dc.subjectMelatonin
dc.subjectPeriodontal diseases
dc.subjectPineal gland
dc.titleMelatonin promotes reduction in TNF levels and improves the lipid profile and insulin sensitivity in pinealectomized rats with periodontal diseaseen
dc.typeArtigopt
dspace.entity.typePublication
relation.isOrgUnitOfPublication8b3335a4-1163-438a-a0e2-921a46e0380d
relation.isOrgUnitOfPublication.latestForDiscovery8b3335a4-1163-438a-a0e2-921a46e0380d
unesp.author.orcid0000-0003-3753-229X 0000-0003-3753-229X[10]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araçatubapt
unesp.departmentCiências Básicas - FOApt
unesp.departmentOdontologia Infantil e Social - FOApt

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