Publicação: Circulating tumor cell isolation from clinical samples utilizing a lateral filter array microfluidic device
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Isolation methods of circulating tumor cells (CTCs) usually rely on either immunoaffinity or size-based separation. However, immunoaffinity methods miss CTCs under-expressing surface markers of interest. Size-based methods miss CTCs with a size less than the filter geometry designed. We have developed a lateral filter array microfluidic (LFAM) device that integrates size-based separation with immunoaffinity-based isolation. We have demonstrated that the LFAM device improves CTC capture from blood samples of colorectal cancer patients when compared to a microfluidic device using either size-based filtration only or immunoaffinity alone.
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Circulating tumor cells, Colorectal Cancer, Filtration, Immunoaffinity
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Inglês
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23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019, p. 1514-1515.
