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Protocol to refine intestinal motility test in mice

dc.contributor.authorMarona, Hérida Regina Nunes [UNESP]
dc.contributor.authorLucchesi, Maria Beatriz Bastos [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:21:06Z
dc.date.available2014-05-27T11:21:06Z
dc.date.issued2004-07-01
dc.description.abstractWe propose a new protocol intended to conform to the 3Rs (replacement, reduction, and refinement) principle, using animals fasted for 3 h to control intestinal motility, which reduced stress in the animals. In this new protocol, mice are deprived of food for a short time (3 h) and are not killed. The mice are observed until evacuation containing charcoal is observed, and the experimental results are based on the charcoal evacuation time. The present study may aid the formulation of recommendations that can be included in revised guidelines relating to the fasting time of mice. This new concept of an intestinal motility test conforms with respectful science.en
dc.description.affiliationDepto. de Farmacos e Medicamentos Faculdade de Cie. Farmaceuticas Universidade Estadual Paulista, Rodovia Araraquara-Jaú, km 1, CEP 14801-902, Araraquara, SP
dc.description.affiliationUnespDepto. de Farmacos e Medicamentos Faculdade de Cie. Farmaceuticas Universidade Estadual Paulista, Rodovia Araraquara-Jaú, km 1, CEP 14801-902, Araraquara, SP
dc.format.extent257-260
dc.identifierhttp://dx.doi.org/10.1258/002367704323133637
dc.identifier.citationLaboratory Animals, v. 38, n. 3, p. 257-260, 2004.
dc.identifier.doi10.1258/002367704323133637
dc.identifier.issn0023-6772
dc.identifier.scopus2-s2.0-3242664151
dc.identifier.urihttp://hdl.handle.net/11449/67776
dc.identifier.wosWOS:000222755100004
dc.language.isoeng
dc.relation.ispartofLaboratory Animals
dc.relation.ispartofjcr1.450
dc.relation.ispartofsjr0,665
dc.rights.accessRightsAcesso restritopt
dc.sourceScopus
dc.subjectAnimal welfare
dc.subjectIn vivo test
dc.subjectIntestinal motility
dc.subjectLoperamide
dc.subjectcharcoal
dc.subjectanimal experiment
dc.subjectcontrolled study
dc.subjectdiet restriction
dc.subjectfemale
dc.subjectintestine motility
dc.subjectintestine transit time
dc.subjectmethodology
dc.subjectmouse
dc.subjectnonhuman
dc.subjectstress
dc.subjecttime
dc.subjectAnimal Use Alternatives
dc.subjectAnimals
dc.subjectAnimals, Laboratory
dc.subjectCharcoal
dc.subjectFasting
dc.subjectGastrointestinal Motility
dc.subjectMice
dc.subjectTime Factors
dc.subjectAnimalia
dc.titleProtocol to refine intestinal motility test in miceen
dc.typeArtigopt
dcterms.licensehttp://www.sagepub.com/authors/journal/permissions.sp#7
dspace.entity.typePublication
relation.isDepartmentOfPublicatione214da1b-9929-4ae9-b8fd-655e9bfeda4b
relation.isDepartmentOfPublication.latestForDiscoverye214da1b-9929-4ae9-b8fd-655e9bfeda4b
relation.isOrgUnitOfPublication95697b0b-8977-4af6-88d5-c29c80b5ee92
relation.isOrgUnitOfPublication.latestForDiscovery95697b0b-8977-4af6-88d5-c29c80b5ee92
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentFármacos e Medicamentos - FCFpt

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