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Chrysin protects against behavioral, cognitive and neurochemical alterations in a 6-hydroxydopamine model of Parkinson's disease

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dc.contributor.authorDel Fabbro, Lucian
dc.contributor.authorGoes, Andre Rossito
dc.contributor.authorJesse, Cristiano Ricardo
dc.contributor.authorGomes, Marcelo Gomes de
dc.contributor.authorSouza, Leandro Cattelan
dc.contributor.authorLobo Ladd, Fernando V.
dc.contributor.authorLobo Ladd, Aliny A. B.
dc.contributor.authorNunes Arantes, Ricardo Vinicius
dc.contributor.authorSimionato, Astor Reis [UNESP]
dc.contributor.authorOliveira, Mauro Schneider
dc.contributor.authorFurian, Ana Flavia
dc.contributor.authorBoeira, Silvana Peterini
dc.contributor.institutionFed Univ Pampa
dc.contributor.institutionFed Univ Pampa Campus
dc.contributor.institutionUniv Fed Rio Grande do Norte
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Sergipe (UFS)
dc.date.accessioned2019-10-04T19:54:53Z
dc.date.available2019-10-04T19:54:53Z
dc.date.issued2019-07-27
dc.description.abstractParkinson's disease (PD) is an age-related neurodegenerative disorder that severely affects quality of life of patients and their families. The flavonoid chrysin (5,7-dihydroxylflavone) is a naturally occurring flavone with several pharmacological activities, including anti-inflammatory and anti-oxidative. We investigated the effects of a 28-day chrysin treatment (10 mg/kg/day, i.g.) on a model of PD induced by 6-OHDA in aged (20-month old) mice. We found a protective effect of chrysin on behavioral and cognitive alterations (rotational behavior, passive avoidance and Barnes maze tests), nitric oxide synthesis (NOx), lipid peroxidation (HNE), glutathione levels (GSH), reactive species levels (RS), neuroinflammation (interleukin-1 beta - IL-1 beta and tumor necrosis factor alpha- TNF-alpha), Na+, K+-ATPase and nicotinamide adenine dinucleotide phosphate oxidase activity (NADPH oxidase) activities. In addition, chrysin protected against changes in striatal dopamine (DA), 3,4-di-hydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) levels. In conclusion, chrysin improved several behavioral, cognitive and neurochemical parameters in a relevant preclinical model of PD in aged mice.en
dc.description.affiliationFed Univ Pampa, Lab Pharmacol & Toxicol Evaluat Appl Bioact Mol L, Campus Itaqui, BR-97650000 Itaqui, RS, Brazil
dc.description.affiliationFed Univ Pampa Campus, Postgrad Program Pharmaceut Sci, Uruguaiana, RS, Brazil
dc.description.affiliationUniv Fed Rio Grande do Norte, Biosci Ctr, Lab Neuroanat, Dept Morphol, Natal, RN, Brazil
dc.description.affiliationUniv Sao Paulo, Coll Vet Med & Anim Sci, Dept Surg, Lab Stochast Stereol & Chem Anat, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Bauru Dent Sch, Dept Biol Sci, Lab Histol, Sao Paulo, SP, Brazil
dc.description.affiliationSao Paulo State Univ, Lab Optimizat Sports Performance Human LaBOEH, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Santa Maria, Lab Neurotox & Psychopharmacol LABNEURO, Santa Maria, RS, Brazil
dc.description.affiliationUniv Fed Santa Maria, Lab Pharmacol Mycotoxins & Toxicol LAFARMT, Santa Maria, RS, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Lab Optimizat Sports Performance Human LaBOEH, Sao Paulo, SP, Brazil
dc.description.sponsorshipFundacao de apoio a pesquisa do Estado do Rio Grande do Sul (FAPERGS)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFundacao de apoio a pesquisa do Estado do Rio Grande do Sul (FAPERGS): 16/2551-0000526-5
dc.description.sponsorshipIdFundacao de apoio a pesquisa do Estado do Rio Grande do Sul (FAPERGS): 16/2251-0000183-9
dc.description.sponsorshipIdCAPES: 001
dc.format.extent158-163
dc.identifierhttp://dx.doi.org/10.1016/j.neulet.2019.05.036
dc.identifier.citationNeuroscience Letters. Clare: Elsevier Ireland Ltd, v. 706, p. 158-163, 2019.
dc.identifier.doi10.1016/j.neulet.2019.05.036
dc.identifier.issn0304-3940
dc.identifier.urihttp://hdl.handle.net/11449/186372
dc.identifier.wosWOS:000473249700026
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNeuroscience Letters
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectNeuroinflammation
dc.subjectOxidative stress
dc.subjectBehavior
dc.subjectDopaminergic neurons
dc.subjectOld-mice
dc.titleChrysin protects against behavioral, cognitive and neurochemical alterations in a 6-hydroxydopamine model of Parkinson's diseaseen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
unesp.author.orcid0000-0003-3613-4134[1]
unesp.author.orcid0000-0001-9017-5979[4]
unesp.departmentCiências Biológicas - FCpt

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