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Effect of propolis extract on guines pig lung mast cell

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dc.contributor.authorOrsi, R. O. [UNESP]
dc.contributor.authorSforcin, J. M. [UNESP]
dc.contributor.authorFunari, S. R. C. [UNESP]
dc.contributor.authorGomes, J. C. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2021-07-14T10:30:35Z
dc.date.available2021-07-14T10:30:35Z
dc.date.issued2005-03
dc.description.abstractThe direct effect of ethanolic extract of propolis on guinea pig lung cell suspension containing mast cells, as well as its influence on the histamine release induced by antigen (ovoalbumin 10 mug/ml) and ionophore A 23187 (3 muM) were investigated. Propolis ethanolic extract (300 mug/ml) increased the histamine release in guinea pig lung suspension containing mast cells by a cytotoxic effect. Lower concentrations of propolis had no effect on histamine release. Our results demonstrated that propolis (3, 10, 30, and 100 mug/ml) shows no significant effect on the histamine release induced by ionophore and antigen. Based on these results, we suggest that propolis could directly activate mast cells, promoting inflammatory mediators release by cytotoxic mechanisms, what could be related to allergic processes in propolis sensitive people.en
dc.description.affiliationUniversidade Estadual Paulista, School of Veterinary Medicine and Animal Husbrandy
dc.description.affiliationUniversidade Estadual Paulista, Institute of Biosciences
dc.description.affiliationUnespUniversidade Estadual Paulista, School of Veterinary Medicine and Animal Husbrandy
dc.description.affiliationUnespUniversidade Estadual Paulista, Institute of Biosciences
dc.format.extent76-83
dc.identifierhttp://dx.doi.org/10.1590/S1678-91992005000100009
dc.identifier.citationJournal of Venomous Animals and Toxins including Tropical Diseases. Botucatu, SP, Brazil: Centro de Estudos de Venenos e Animais Peçonhentos, v. 11, n. 1, p. 76-83, 2005.
dc.identifier.doi10.1590/S1678-91992005000100009
dc.identifier.fileS1678-91992005000100009.pdf
dc.identifier.issn1678-9199
dc.identifier.scieloS1678-91992005000100009
dc.identifier.urihttp://hdl.handle.net/11449/211848
dc.language.isoeng
dc.publisherCentro de Estudos de Venenos e Animais Peçonhentos
dc.relation.ispartofJournal of Venomous Animals and Toxins including Tropical Diseases
dc.rights.accessRightsAcesso aberto
dc.sourceSciELO
dc.subjectmast cellsen
dc.subjectallergyen
dc.subjecthistamineen
dc.subjectpropolisen
dc.titleEffect of propolis extract on guines pig lung mast cellen
dc.typeArtigo
dspace.entity.typePublication

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