Emperipolesis in a Case of B-Cell Lymphoma: A Rare Phenomenon Outside of Rosai-Dorfman Disease

We describe a case of a diffuse large B-cell lymphoma with extensive emperipolesis phenomenon. Light microscopy revealed numerous CD68-positive/S-100-negative histiocytes containing viable neoplastic hematopoietic cells in their cytoplasm. Electron microscopy confirmed these findings. In this case, there was no evidence of Rosai-Dorfman disease either clinically or histologically. This report emphasizes that emperipolesis is not restricted to Rosai-Dorfman disease and can be found in other conditions including non-Hodgkin lymphomas. © 2003 Elsevier Inc. All rights reserved.

Keywords

Electron microscopy, Emperipolesis, Immunohistochemistry, Lymphoma, Rosai-Dorfman disease, antineoplastic agent, CD68 antigen, protein S 100, aged, B cell lymphoma, cancer chemotherapy, cancer regression, case report, cell type, cytoplasm, electron microscopy, emperipolesis, hematopoietic cell, histiocyte, histopathology, human, human tissue, immunohistochemistry, male, microscopy, phagocytosis, priority journal, Rosai Dorfman disease, Aged, Antineoplastic Agents, Cytoplasm, Histiocytosis, Sinus, Humans, Immunoenzyme Techniques, Lymph Nodes, Lymphoma, B-Cell, Male, Treatment Outcome, Tumor Markers, Biological