Publicação:
Therapeutic option for children with esophageal caustic stenosis

dc.contributor.authorOrtolan, Érika Veruska Paiva [UNESP]
dc.contributor.authorBustamante, Thais França
dc.contributor.authorTakegawa, Bonifácio Katsunori [UNESP]
dc.contributor.authorMendonça, Fernanda Alves
dc.contributor.authorRodrigues, Antonio Marcos
dc.contributor.authorMendes, Élson Felix
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-27T11:23:35Z
dc.date.available2014-05-27T11:23:35Z
dc.date.issued2008-07-01
dc.description.abstractCaustic ingestion is a leading cause of esophageal stenosis in children. Herein we report four cases using mitomycin C (MMC), a drug that inhibits cell division, protein synthesis and fibroblast proliferation and has been used as an adjuvant therapy for caustic esophageal stenosis that is recalcitrant to conventional dilation techniques. A retrospective chart review was performed on four pediatric patients with severe, recurrent esophageal stricture after caustic ingestion. The patients had required six to 20 esophageal dilations over a 4-16-month period before MMC application. MMC was applied after an endoscopic dilation on saturated pledgets at a dose of 0.1 mg/mL for 2 min in the area where the strictures had been lyzed. From the four children treated with MMC, two have been asymptomatic for 16 and 20 months and two still require esophageal dilation, however, at longer intervals. All patients have shown satisfactory weight gain with food intake exclusively per oral. Although further studies are required, there is strong evidence that MMC is a safe and effective adjuvant therapy in the treatment of esophageal caustic stenosis. © 2008 The Authors.en
dc.description.affiliationBotucatu School of Medicine Department of Surgery, Rubião Jr s/n, Botucatu, SP 18618-970
dc.description.affiliationState of Sao Paulo University Botucatu School of Medicine, Botucatu, SP
dc.format.extent146-149
dc.identifierhttp://dx.doi.org/10.1111/j.1443-1661.2008.00794.x
dc.identifier.citationDigestive Endoscopy, v. 20, n. 3, p. 146-149, 2008.
dc.identifier.doi10.1111/j.1443-1661.2008.00794.x
dc.identifier.issn0915-5635
dc.identifier.issn1443-1661
dc.identifier.scopus2-s2.0-44649178168
dc.identifier.urihttp://hdl.handle.net/11449/70452
dc.language.isoeng
dc.relation.ispartofDigestive Endoscopy
dc.relation.ispartofjcr3.375
dc.relation.ispartofsjr1,324
dc.relation.ispartofsjr1,324
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectCaustic stenosis
dc.subjectEsophageal stenosis
dc.subjectMitomycin C
dc.subjectmitomycin C
dc.subjectadjuvant therapy
dc.subjectcase report
dc.subjectchild
dc.subjectesophagitis
dc.subjectesophagoscopy
dc.subjectesophagus stenosis
dc.subjectesophagus surgery
dc.subjectfemale
dc.subjecthuman
dc.subjectmale
dc.subjectmedical record review
dc.subjectsurgical technique
dc.subjecttreatment outcome
dc.subjecttreatment response
dc.titleTherapeutic option for children with esophageal caustic stenosisen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
unesp.departmentCirurgia e Ortopedia - FMBpt

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