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Chromosomal imbalances detected in primary bone tumors by comparative genomic hybridization and interphase fluorescence in situ hybridization

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dc.contributor.authorBaruffi, Marcelo Razera
dc.contributor.authorEngel, Edgard Edward
dc.contributor.authorSquire, Jeremy Andrew
dc.contributor.authorTone, Luis Gonzaga
dc.contributor.authorRogatto, Silvia Regina [UNESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversity Health Network Princess Margaret Hospital Ontario Cancer Institute
dc.contributor.institutionUniversity of Toronto Department of Medical Biophysics
dc.contributor.institutionUniversity of Toronto Department of Laboratory Medicine and Pathobiology
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:17:25Z
dc.date.available2014-05-20T15:17:25Z
dc.date.issued2003-01-01
dc.description.abstractWe applied a combination of comparative genomic hybridization (CGH) and fluorescence in situ hybridization (FISH), to characterize the genetic aberrations in three osteosarcomas (OS) and one Ewing's sarcoma. CGH identified recurrent chromosomal losses at 10p14-pter and gains at 8q22.3-24.1 in OS. Interphase FISH allowed to confirm 8q gain in two cases. A high amplification level of 11q12-qter was detected in one OS. The Ewing's sarcoma showed gain at 1p32-36.1 as the sole chromosome alteration. These studies demonstrate the value of molecular cytogenetic methods in the characterization of recurrent genomic alterations in bone tumor tissue.en
dc.description.affiliationUSP Faculdade de Medicina Departamento de Puericultura e Pediatria
dc.description.affiliationUSP Faculdade de Medicina Departamento de Biomecânica, Medicina e Reabilitação do Aparelho Locomotor
dc.description.affiliationUniversity Health Network Princess Margaret Hospital Ontario Cancer Institute
dc.description.affiliationUniversity of Toronto Department of Medical Biophysics
dc.description.affiliationUniversity of Toronto Department of Laboratory Medicine and Pathobiology
dc.description.affiliationUNESP Instituto de Biociências Departmento de Genética
dc.description.affiliationUnespUNESP Instituto de Biociências Departmento de Genética
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent107-113
dc.identifierhttp://dx.doi.org/10.1590/S1415-47572003000200001
dc.identifier.citationGenetics and Molecular Biology. Sociedade Brasileira de Genética, v. 26, n. 2, p. 107-113, 2003.
dc.identifier.doi10.1590/S1415-47572003000200001
dc.identifier.fileS1415-47572003000200001.pdf
dc.identifier.issn1415-4757
dc.identifier.lattes2259986546265579
dc.identifier.lattes6882035465809248
dc.identifier.scieloS1415-47572003000200001
dc.identifier.urihttp://hdl.handle.net/11449/30465
dc.language.isoeng
dc.publisherSociedade Brasileira de Genética
dc.relation.ispartofGenetics and Molecular Biology
dc.relation.ispartofjcr1.493
dc.relation.ispartofsjr0,638
dc.rights.accessRightsAcesso aberto
dc.sourceSciELO
dc.subjectcomparative genomic hybridizationen
dc.subjectCGHen
dc.subjectosteosarcomaen
dc.subjectEwing's Sarcomaen
dc.titleChromosomal imbalances detected in primary bone tumors by comparative genomic hybridization and interphase fluorescence in situ hybridizationen
dc.typeArtigo
dspace.entity.typePublication
unesp.author.lattes2259986546265579
unesp.author.lattes6882035465809248
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
unesp.departmentUrologia - FMBpt

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Botucatu - FMB - Faculdade de Medicina