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Prognostic significance of Ki67 and its correlation with mitotic index in dogs with diffuse large B-cell lymphoma treated with 19-week CHOP-based protocol

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dc.contributor.authorSierra Matiz, Oscar R. [UNESP]
dc.contributor.authorSantilli, Juliana
dc.contributor.authorAnai, Leticia A. [UNESP]
dc.contributor.authorDa Silva, Maria C. L. [UNESP]
dc.contributor.authorSueiro, Felipe A.
dc.contributor.authorSequeira, Júlio L. [UNESP]
dc.contributor.authorMagalhães, Larissa F.
dc.contributor.authorMagalhães, Geórgia M.
dc.contributor.authorTinucci Costa, Mirela [UNESP]
dc.contributor.authorCalazans, Sabryna G. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionFranca University
dc.contributor.institutionVeterinary Laboratory VetPat
dc.contributor.institutionScience and Technology of the South of Minas Gerais
dc.date.accessioned2018-12-11T16:51:50Z
dc.date.available2018-12-11T16:51:50Z
dc.date.issued2018-03-01
dc.description.abstractDiffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma in dogs. We evaluated Ki67 immunoexpression and mitotic index (MI) in dogs diagnosed with DLBCL and treated with a 19-wk CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) protocol. Twenty-nine lymph node samples from dogs diagnosed with DLBCL were analyzed for Ki67 immunostaining, and positive cells present in 1 cm2 were counted in a grid reticle for comparison of survival times above and below the means. The Ki67 mean was 107, and the MI mean was 21. There was a significant (p < 0.05) difference in median survival time between Ki67 immunostaining above and below the mean, with no difference in MI groups. Ki67 values >107 positive cells per 5 HPF counted in a grid reticle were associated with shorter survival times in dogs with DLBCL treated with a 19-wk CHOP-based protocol.en
dc.description.affiliationClinical Veterinary Department College of Agricultural and Veterinary Sciences São Paulo State University ‘Júlio de Mesquita Filho’ (UNESP)
dc.description.affiliationCollege of Veterinary Medicine Franca University
dc.description.affiliationPathology Veterinary Department College of Veterinary and Zootechnical Medicine São Paulo State University Júlio de Mesquita Filho
dc.description.affiliationVeterinary Laboratory VetPat
dc.description.affiliationPathology Department Federal Institute of Education Science and Technology of the South of Minas Gerais, Campus of Muzambinho
dc.description.affiliationUnespClinical Veterinary Department College of Agricultural and Veterinary Sciences São Paulo State University ‘Júlio de Mesquita Filho’ (UNESP)
dc.description.affiliationUnespPathology Veterinary Department College of Veterinary and Zootechnical Medicine São Paulo State University Júlio de Mesquita Filho
dc.format.extent263-267
dc.identifierhttp://dx.doi.org/10.1177/1040638717743280
dc.identifier.citationJournal of Veterinary Diagnostic Investigation, v. 30, n. 2, p. 263-267, 2018.
dc.identifier.doi10.1177/1040638717743280
dc.identifier.file2-s2.0-85041716652.pdf
dc.identifier.issn1943-4936
dc.identifier.issn1040-6387
dc.identifier.lattes3409765424060945
dc.identifier.scopus2-s2.0-85041716652
dc.identifier.urihttp://hdl.handle.net/11449/170645
dc.language.isoeng
dc.relation.ispartofJournal of Veterinary Diagnostic Investigation
dc.relation.ispartofsjr0,621
dc.rights.accessRightsAcesso abertopt
dc.sourceScopus
dc.subjectCell proliferation
dc.subjectdogs
dc.subjectimmunohistochemistry
dc.subjectmitosis
dc.subjectprognosis
dc.titlePrognostic significance of Ki67 and its correlation with mitotic index in dogs with diffuse large B-cell lymphoma treated with 19-week CHOP-based protocolen
dc.typeArtigopt
dspace.entity.typePublication
unesp.advisor.lattes3409765424060945
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt

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