Efeitos da terapia fotodinâmica antimicrobiana em leveduras do gênero Candida
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Abstract
The aim of this study was to evaluate the effects of photodynamic therapy using methylene blue on Candida strains. Were studied: 5 C. albicans, 4 C. tropicalis, 4 C. glabrata 2 C. parapsilosis, 2 C. kefyr, 1 C. stellatoidea, 1 C. krusei and 1 C. lipolytica. Each strain was underwent to four experimental conditions: methylene blue laser (L+P+) irradiation with laser (L+P-), treatment with methylene blue (L-P+), and treatment with saline as control group (L-P-). After treatment of each strain and plating serial dilutions on Sabouraud dextrose agar were performed. The data from colony forming units per milliliter (CFU/ml) were analyzed by ANOVA and Tukey test (p <0.05). The results suggest that the groups treated with laser (L+ P+ and L+P-) showed average CFU/ml (Log) lower than without laser treatment groups (L-F- e L-F+). The group with photodynamic therapy (L+P+) showed an average CFU/ml (Log) similar to the group (L+P-). It was concluded that the strains of Candida analyzed were sensitive to laser irradiation of low power in the presence or absence of methylene blue.
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Candida spp, Lowpower laser, Methylene blue, Photodynamic therapy
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Portuguese
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Revista de Ciencias Farmaceuticas Basica e Aplicada, v. 35, n. 4, p. 663-669, 2014.
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