Efeito da lavagem peritoneal com bupivacaína na sobrevida de ratos com peritonite fecal
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Elsevier
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BACKGROUND AND OBJECTIVES: Based on the knowledge of the anti-inflammatory and anti-bacterial actions of local anesthetics (LA), the objective of this study was to determine the effects of peritoneal lavage with bupivacaine on survival of mice with fecal peritonitis. METHODS: Forty-eight Wistar mice, weighing between 300 and 330 g (311.45 ± 9.67 g), undergoing laparotomy 6 hours after induction of peritonitis were randomly divided in 4 groups: 1 - Control, without treatment (n = 12); 2 - Drying of the abdominal cavity (n = 12); 3 - Lavage with 3 mL NS and posterior drying of the abdominal cavity (n = 12); and 4 - Lavage with 8 mg.kg -1 (± 0.5 mL) of 0.5% bupivacaine added to 2.5 mL of NS followed by drying out of the abdominal cavity (n = 12). Animals that died underwent necropsy and the time of death was recorded. Surviving animals were killed on the 11 th postoperative day and underwent necropsy. RESULTS: Group 1 presented a 100% mortality rate in 52 hours, 100% mortality rate in Group 2 in 126 hours, and Group 3 presented a 50% mortality rate in 50 hours. Animals in Group 4 survived. Survival on the 11 th day was greater in groups 3 and 4 than in Groups 1 and 2 (p < 0.001) and greater in Group 4 than in Group 3 (p < 0.01). CONCLUSIONS: Peritoneal lavage with a solution of bupivacaine diluted in NS was effective in preventing death for 11 days in 100% of animals with fecal peritonitis. © Sociedade Brasileira de Anestesiologia, 2008.
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Anesthetic, local: Bupivacaine , Animals: Mice , Complications, infection: Peritonitis , amikacin , aminoglycoside antibiotic agent , amoxicillin plus clavulanic acid , ampicillin , antibiotic agent , bupivacaine , cefazolin , ceftriaxone , cephalosporin derivative , ciprofloxacin , clindamycin , cotrimoxazole , erythromycin , gatifloxacin , gentamicin , ketamine , levofloxacin , lidocaine , linezolid , local anesthetic agent , nitrofurantoin , norfloxacin , oxacillin , penicillin derivative , quinoline derived antiinfective agent , rifampicin , ropivacaine , sultamicillin , unindexed drug , vancomycin , animal experiment , animal model , antibacterial activity , antibiotic sensitivity , antiinflammatory activity , controlled study , drug effect , feces , Gram negative bacterium , Gram positive bacterium , immune response , laparotomy , mortality , mouse , nonhuman , peritoneal cavity , peritoneum lavage , peritonitis , sepsis , survival rate
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Português
Citação
Revista Brasileira de Anestesiologia, v. 58, n. 5, p. 470-479, 2008.
