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Publicação:
Modulation of thyroid hormone receptors, TR alpha and TR beta, by using different doses of triiodothyronine (T3) at different times

dc.contributor.authorOliveira, Miriane de [UNESP]
dc.contributor.authorMelo Luvizotto, Renata de Azevedo [UNESP]
dc.contributor.authorCastro Olimpio, Regiane Marques [UNESP]
dc.contributor.authorSibio, Maria Teresa de [UNESP]
dc.contributor.authorRodrigues Silva, Carolina Biz
dc.contributor.authorConde, Sandro Jose [UNESP]
dc.contributor.authorPadovani, Carlos Roberto [UNESP]
dc.contributor.authorNogueira, Celia Regina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2014-12-03T13:10:51Z
dc.date.available2014-12-03T13:10:51Z
dc.date.issued2013-07-01
dc.description.abstractObjective: To examine the effect of different doses of triiodothyronine (T3) on mRNA levels of thyroid hormone receptors, TR alpha and TR beta, at different times. Materials and methods: 3T3-L1 adipocytes were incubated with T3 (physiological dose: F; supraphysiological doses: SI or SII), or without T3 (control, C) for 0.5, 1, 6, or 24h. TR alpha and TR beta mRNA was detected using real-time polymerase chain reaction. Results: F increased TR beta mRNA levels at 0.5h. After 1h, TR alpha levels increased with F and SI and TR beta levels decreased with SII compared with C, F, and SI. After 6h, both genes were suppressed at all concentrations. In 24h, TR alpha and TR beta levels were similar to those of C group. Conclusions: T3 action with F began at 1h for TR alpha and at 0.5h for TR beta. These results suggest the importance of knowing the times and doses that activate T3 receptors in adipocytes.en
dc.description.affiliationSao Paulo State Univ Unesp, Botucatu Med Sch, Dept Internal Clin, Botucatu, SP, Brazil
dc.description.affiliationSao Paulo Fed Univ Unifesp, Dept Physiol, Sao Paulo, Brazil
dc.description.affiliationUNESP, Biosci Inst, Dept Biostat, Botucatu, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ Unesp, Botucatu Med Sch, Dept Internal Clin, Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Biosci Inst, Dept Biostat, Botucatu, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 10/16911-4
dc.format.extent368-374
dc.identifierhttp://dx.doi.org/10.1590/S0004-27302013000500006
dc.identifier.citationArquivos Brasileiros de Endocrinologia e Metabologia. Rio de Janeiro, Rj: Sbem-soc Brasil Endocrinologia & Metabologia, v. 57, n. 5, p. 368-374, 2013.
dc.identifier.doi10.1590/S0004-27302013000500006
dc.identifier.fileS0004-27302013000500006.pdf
dc.identifier.issn0004-2730
dc.identifier.issn1677-9487
dc.identifier.lattes8727897080522289
dc.identifier.scieloS0004-27302013000500006
dc.identifier.scopus2-s2.0-84880955870
dc.identifier.urihttp://hdl.handle.net/11449/132408
dc.identifier.wosWOS:000322398100006
dc.language.isoeng
dc.publisherSbem-soc Brasil Endocrinologia & Metabologia
dc.relation.ispartofArquivos Brasileiros de Endocrinologia & Metabologia
dc.relation.ispartofjcr1.515
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectTR alphaen
dc.subjectTR betaen
dc.subjecttriiodothyronineen
dc.subjectadipocytesen
dc.titleModulation of thyroid hormone receptors, TR alpha and TR beta, by using different doses of triiodothyronine (T3) at different timesen
dc.title.alternativeModulação dos receptores de hormônio tireoidiano, TRα e TRβ, utilizando diferentes doses de triiodotironina (T3) em diferentes tempospt
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/abem/paboutj.htm
dcterms.rightsHolderSbem-soc Brasil Endocrinologia & Metabologia
dspace.entity.typePublication
unesp.author.lattes8727897080522289[7]
unesp.author.lattes7607038776901890[8]
unesp.author.orcid0000-0002-7354-9518[8]
unesp.author.orcid0000-0002-7719-9682[7]
unesp.author.orcid0000-0002-4014-0660[8]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.departmentBioestatística - IBBpt

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