Logo do repositório
 

Chemical composition, in vitro cytotoxic and anticholinesterase activities of flower extracts of Senna spectabilis var. excelsa and Senna macranthera

dc.contributor.authorFranca, Maria G. A.
dc.contributor.authorPessoa, Cláudia O.
dc.contributor.authorTrevisan, Maria T. S.
dc.contributor.authorPaiva, Cristiane F.
dc.contributor.authorLima, Daniele R.
dc.contributor.authorSousa, Anderson F.
dc.contributor.authorOliveira, Fátima C. E.
dc.contributor.authorCavalheiro, Alberto J. [UNESP]
dc.contributor.authorSilva, Maria G. V.
dc.contributor.institutionFederal University of Ceará
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-05-01T10:51:11Z
dc.date.available2022-05-01T10:51:11Z
dc.date.issued2021-01-01
dc.description.abstractIn this study, we investigated the phenolic and antioxidant content, cytotoxic, and anticholinesterase activities of flower extracts of Senna spectabilis var. excelsa and Senna macranthera. The antioxidant activities performed by the DPPH and ABTS methods showed that the extracts possess good antioxidant activity, with emphasis on the S. macranthera extract, which obtained results very similar to the rutin pattern. In the evaluation of the cytotoxic activity, the species S. spectabilis var. excelsa presented expressive cytotoxicity against the cellular lines PC3 and HL60 with IC50 values 21.08 and 31.37 μg mL−1, respectively. The results of anticholinesterase activity showed that both the plants induced enzyme inhibition, reaching 14 mm of inhibition in the case of S. spectabilis var. excelsa. The good results obtained in this work may be related to the presence of compounds such as apigenin-7-apioglucoside, quercetin 3,4'-diglucoside, cassine and spectaline identified in the extracts in our previous work.en
dc.description.affiliationDepartment of Organic and Inorganic Chemistry/Department of Analytical Chemistry and Physical-Chemistry Federal University of Ceará
dc.description.affiliationDepartment of Physiology and Pharmacology Federal University of Ceará
dc.description.affiliationChemistry Institute São Paulo State University - UNESP
dc.description.affiliationUnespChemistry Institute São Paulo State University - UNESP
dc.identifierhttp://dx.doi.org/10.1080/14786419.2021.2005052
dc.identifier.citationNatural Product Research.
dc.identifier.doi10.1080/14786419.2021.2005052
dc.identifier.issn1478-6427
dc.identifier.issn1478-6419
dc.identifier.scopus2-s2.0-85119657159
dc.identifier.urihttp://hdl.handle.net/11449/233829
dc.language.isoeng
dc.relation.ispartofNatural Product Research
dc.sourceScopus
dc.subjectacetylcholinesterase
dc.subjectantioxidant
dc.subjectcytotoxicity
dc.subjectSenna
dc.titleChemical composition, in vitro cytotoxic and anticholinesterase activities of flower extracts of Senna spectabilis var. excelsa and Senna macrantheraen
dc.typeArtigopt
dspace.entity.typePublication
relation.isOrgUnitOfPublicationbc74a1ce-4c4c-4dad-8378-83962d76c4fd
relation.isOrgUnitOfPublication.latestForDiscoverybc74a1ce-4c4c-4dad-8378-83962d76c4fd
unesp.author.orcid0000-0001-6906-0501[1]
unesp.author.orcid0000-0002-4344-4336[2]
unesp.author.orcid0000-0003-1274-7497[3]
unesp.author.orcid0000-0001-8835-2382[4]
unesp.author.orcid0000-0002-7957-575X[5]
unesp.author.orcid0000-0003-1459-5669[6]
unesp.author.orcid0000-0002-4737-5008[7]
unesp.author.orcid0000-0001-8214-9957[8]
unesp.author.orcid0000-0002-7062-4834[9]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.departmentQuímica Orgânica - IQARpt

Arquivos