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Antiviral activity of plants occurring in the state of minas gerais (Brazil): Part III

dc.contributor.authorBrandão, Geraldo Célio
dc.contributor.authorKroon, Erna G.
dc.contributor.authordos Santos, João Rodrigues
dc.contributor.authorStehmann, João Renato
dc.contributor.authorLombardi, Júlio A. [UNESP]
dc.contributor.authorde Oliveira, Alaíde Braga
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:25:58Z
dc.date.available2014-05-27T11:25:58Z
dc.date.issued2011-08-12
dc.description.abstractA total of 24 extracts from 14 plant species collected at the state of Minas Gerais, Brazil, and belonging to five botanical families (Annonaceae, Apocynaceae, Ochnaceae, Polygonaceae and Vitaceae) was screened for cytotoxicity in cultured Vero cells and for antiviral activity against human herpes virus type 1 (HSV-1), vaccinia virus (VACV) and murine encephalomyocarditis virus (EMCV). The highest cytotoxicity (CC 50 < 10 μg/mL) was observed for the ethanol extracts from Annona coriacea fruits and seeds. Extracts from Hancornia speciosa, Ouratea castaneafolia and O. semisrrata were the only ones that have shown activity against all the three viruses assayed. Extracts from Polygonum spectabile, Hancornia speciosa, Himatanthus phagedaenica, Ouratea spectabilis and O. semiserrata were the most active against HSV-1 (EC 50 < 50 mg/mL), with favorable SI values (8.0 to 10.0). Hancornia speciosa and Anaxagorea dolichocarpa were the most active against EMCV (EC 50 50 - 100 μg/mL), with reasonable SI values (5.2 to 6.1), while moderate to low activity (EC 50 > 100 μg/mL) was observed for Ouratea spectabilis and O. semiserrata. A total of 7 plant species, Ouratea semiserrata, O. spectabilis, O. castanaeafolia, Rollinia laurifolia, Cissus erosa, Polygonum spectabile, and Hancornia speciosa, were active against VACV, disclosing EC50 < 50 μg/mL and SI values ranging from 6.6 to 67.3. In total, 10 out of the 14 species were selected from a literature survey on plants used to treat viral diseases in Brazil; these species were responsible for 70% of the positive results.en
dc.description.affiliationLaboratório de Fitoquímica Departamento de Produtos Farmacêuticos Faculdade de Farmácia, Universidade Federal de Minas Gerais - UFMG, Av. Antonio Carlos, 6627, CEP 31270-901 Belo Horizonte MG
dc.description.affiliationLaboratório de Vírus Departamento de Microbiologia - ICB Universidade Federal de Minas Gerais-UFMG
dc.description.affiliationLaboratório de Taxonomia Vegetal Departamento de Botânica - ICB Universidade Federal de Minas Gerais-UFMG
dc.description.affiliationDepartamento de Botânica Instituto de Biociências de Rio Claro Universidade Estadual Paulista - UNESP
dc.description.affiliationUnespDepartamento de Botânica Instituto de Biociências de Rio Claro Universidade Estadual Paulista - UNESP
dc.format.extent223-236
dc.identifierhttp://jocpr.com/vol3-iss4-2011/JCPR-2011-3-4-223-236.pdf
dc.identifier.citationJournal of Chemical and Pharmaceutical Research, v. 3, n. 4, p. 223-236, 2011.
dc.identifier.issn0975-7384
dc.identifier.scopus2-s2.0-79961224438
dc.identifier.urihttp://hdl.handle.net/11449/72603
dc.language.isoeng
dc.relation.ispartofJournal of Chemical and Pharmaceutical Research
dc.relation.ispartofsjr0,119
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAntiviral activity
dc.subjectBioprospection
dc.subjectEmcv
dc.subjectHsv-1
dc.subjectVacv
dc.subjectAnaxagorea dolichocarpa extract
dc.subjectAnnona coriacea extract
dc.subjectantivirus agent
dc.subjectAspidosperma cylindrocarpon extract
dc.subjectAspidosperma parvifolium extract
dc.subjectAspidosperma tomentosum extract
dc.subjectCissus erosa extract
dc.subjectHancornia speciosa extract
dc.subjectHimatanthus phagedaenicus extract
dc.subjectOuratea castaneifolia extract
dc.subjectOuratea semiserrata extract
dc.subjectOuratea spectabilis extract
dc.subjectplant extract
dc.subjectPolygonum spectabile extract
dc.subjectRollinia laurifolia extract
dc.subjectTabernaemontana laeta extract
dc.subjectunclassified drug
dc.subjectAnaxagorea dolichocarpa
dc.subjectangiosperm
dc.subjectanimal cell
dc.subjectAnnona coriacea
dc.subjectAnnonaceae
dc.subjectantiviral activity
dc.subjectApocynaceae
dc.subjectAspidosperma cylindrocarpon
dc.subjectAspidosperma parvifolium
dc.subjectAspidosperma tomentosum
dc.subjectBrazil
dc.subjectCissus erosa
dc.subjectcontrolled study
dc.subjectcytotoxicity test
dc.subjectdrug cytotoxicity
dc.subjectdrug screening
dc.subjectfruit
dc.subjectgeographical variation (species)
dc.subjectHancornia speciosa
dc.subjectHerpes simplex virus 1
dc.subjecthigh performance liquid chromatography
dc.subjectHimatanthus phagedaenicus
dc.subjectin vitro study
dc.subjectmouse
dc.subjectMurine encephalomyelitis virus
dc.subjectnonhuman
dc.subjectOchnaceae
dc.subjectOuratea castaneifolia
dc.subjectOuratea semiserrata
dc.subjectOuratea spectabilis
dc.subjectplant leaf
dc.subjectplant seed
dc.subjectPolygonum spectabile
dc.subjectRollinia laurifolia
dc.subjectTabernaemontana laeta
dc.subjectVaccinia virus
dc.subjectVero cell
dc.subjectvirus titration
dc.subjectVitaceae
dc.titleAntiviral activity of plants occurring in the state of minas gerais (Brazil): Part IIIen
dc.typeArtigo
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Rio Claropt
unesp.departmentBotânica - IBpt

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