Publicação: Effects of Short-term Hyper- and Hypoprolactinaemia on Hormones of the Pituitary, Gonad and -Thyroid Axis and on Semen Quality in Male Beagles
dc.contributor.author | Koivisto, M. B. [UNESP] | |
dc.contributor.author | Eschricht, F. | |
dc.contributor.author | Urhausen, C. | |
dc.contributor.author | Hoppen, H. O. | |
dc.contributor.author | Beyerbach, M. | |
dc.contributor.author | Oei, C. H. Y. | |
dc.contributor.author | Guenzel-Apel, A. R. | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Univ Vet Med Hannover | |
dc.contributor.institution | Univ Utrecht | |
dc.date.accessioned | 2014-05-20T15:30:20Z | |
dc.date.available | 2014-05-20T15:30:20Z | |
dc.date.issued | 2009-07-01 | |
dc.description.abstract | Effects of a short-term hyper- and hypoprolactinaemia on serum concentrations of LH, testosterone and semen quality in six male Beagles were investigated. Blood samples were collected at 3-day intervals for 12 weeks. The time span was divided into five 3-week periods: pre-treatment, metoclopramide (MCP) treatment (0.2 mg/kg orally three times daily), cabergoline (CAB) treatment (5 mu g/kg orally once daily), post-treatment 1 and post-treatment 2. In the latter, only semen characteristics were evaluated. Semen parameters were analyzed once per week during the whole 15-week investigation time. At the end of each period, the effects of a single intravenous injection of thyrotropin-releasing hormone (TRH; 10 mu g/kg) on the secretion of prolactin (PRL), LH, testosterone, thyroid-stimulating hormone and thyroxine (T4) were investigated. Pre-treatment serum PRL concentration increased under MCP (p < 0.05), followed by a decrease under CAB administration (p < 0.05). Luteinizing hormone and testosterone concentrations were not affected. Except for straight-line sperm velocity, semen quality did not differ between collection periods. A single iv TRH injection induced a significant PRL increase at 20 min in all experimental periods except during CAB treatment. Luteinizing hormone and testosterone did not show clear TRH-related changes. Basic T4 levels were significantly reduced after CAB treatment ( p < 0.05). The results of the present study demonstrate that MCP-induced short-term hyperprolactinaemia in male beagles does not seriously affect the hypothalamo-pituitary axis and semen quality. | en |
dc.description.affiliation | São Paulo State Univ, Dept Clin Surg & Anim Reprod, São Paulo, Brazil | |
dc.description.affiliation | Univ Vet Med Hannover, Small Anim Clin, Hannover, Germany | |
dc.description.affiliation | Univ Vet Med Hannover, Dept Chem Analyt & Endocrinol, Hannover, Germany | |
dc.description.affiliation | Univ Vet Med Hannover, Dept Biometry Epidemiol & Informat Proc, Hannover, Germany | |
dc.description.affiliation | Univ Utrecht, Fac Vet Med, Dept Farm Anim Hlth, Utrecht, Netherlands | |
dc.description.affiliationUnesp | São Paulo State Univ, Dept Clin Surg & Anim Reprod, São Paulo, Brazil | |
dc.format.extent | 320-325 | |
dc.identifier | http://dx.doi.org/10.1111/j.1439-0531.2009.01425.x | |
dc.identifier.citation | Reproduction In Domestic Animals. Malden: Wiley-blackwell Publishing, Inc, v. 44, p. 320-325, 2009. | |
dc.identifier.doi | 10.1111/j.1439-0531.2009.01425.x | |
dc.identifier.issn | 0936-6768 | |
dc.identifier.lattes | 3725971100777730 | |
dc.identifier.uri | http://hdl.handle.net/11449/39744 | |
dc.identifier.wos | WOS:000267756400068 | |
dc.language.iso | eng | |
dc.publisher | Wiley-Blackwell Publishing, Inc | |
dc.relation.ispartof | Reproduction in Domestic Animals | |
dc.relation.ispartofjcr | 1.422 | |
dc.relation.ispartofsjr | 0,594 | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Web of Science | |
dc.title | Effects of Short-term Hyper- and Hypoprolactinaemia on Hormones of the Pituitary, Gonad and -Thyroid Axis and on Semen Quality in Male Beagles | en |
dc.type | Artigo | |
dcterms.license | http://olabout.wiley.com/WileyCDA/Section/id-406071.html | |
dcterms.rightsHolder | Wiley-blackwell Publishing, Inc | |
dspace.entity.type | Publication | |
unesp.author.lattes | 3725971100777730 | |
unesp.campus | Universidade Estadual Paulista (UNESP), Faculdade de Medicina Veterinária, Araçatuba | pt |
unesp.department | Clínica, Cirurgia e Reprodução Animal - FMVA | pt |
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