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Effects of Short-term Hyper- and Hypoprolactinaemia on Hormones of the Pituitary, Gonad and -Thyroid Axis and on Semen Quality in Male Beagles

dc.contributor.authorKoivisto, M. B. [UNESP]
dc.contributor.authorEschricht, F.
dc.contributor.authorUrhausen, C.
dc.contributor.authorHoppen, H. O.
dc.contributor.authorBeyerbach, M.
dc.contributor.authorOei, C. H. Y.
dc.contributor.authorGuenzel-Apel, A. R.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Vet Med Hannover
dc.contributor.institutionUniv Utrecht
dc.date.accessioned2014-05-20T15:30:20Z
dc.date.available2014-05-20T15:30:20Z
dc.date.issued2009-07-01
dc.description.abstractEffects of a short-term hyper- and hypoprolactinaemia on serum concentrations of LH, testosterone and semen quality in six male Beagles were investigated. Blood samples were collected at 3-day intervals for 12 weeks. The time span was divided into five 3-week periods: pre-treatment, metoclopramide (MCP) treatment (0.2 mg/kg orally three times daily), cabergoline (CAB) treatment (5 mu g/kg orally once daily), post-treatment 1 and post-treatment 2. In the latter, only semen characteristics were evaluated. Semen parameters were analyzed once per week during the whole 15-week investigation time. At the end of each period, the effects of a single intravenous injection of thyrotropin-releasing hormone (TRH; 10 mu g/kg) on the secretion of prolactin (PRL), LH, testosterone, thyroid-stimulating hormone and thyroxine (T4) were investigated. Pre-treatment serum PRL concentration increased under MCP (p < 0.05), followed by a decrease under CAB administration (p < 0.05). Luteinizing hormone and testosterone concentrations were not affected. Except for straight-line sperm velocity, semen quality did not differ between collection periods. A single iv TRH injection induced a significant PRL increase at 20 min in all experimental periods except during CAB treatment. Luteinizing hormone and testosterone did not show clear TRH-related changes. Basic T4 levels were significantly reduced after CAB treatment ( p < 0.05). The results of the present study demonstrate that MCP-induced short-term hyperprolactinaemia in male beagles does not seriously affect the hypothalamo-pituitary axis and semen quality.en
dc.description.affiliationSão Paulo State Univ, Dept Clin Surg & Anim Reprod, São Paulo, Brazil
dc.description.affiliationUniv Vet Med Hannover, Small Anim Clin, Hannover, Germany
dc.description.affiliationUniv Vet Med Hannover, Dept Chem Analyt & Endocrinol, Hannover, Germany
dc.description.affiliationUniv Vet Med Hannover, Dept Biometry Epidemiol & Informat Proc, Hannover, Germany
dc.description.affiliationUniv Utrecht, Fac Vet Med, Dept Farm Anim Hlth, Utrecht, Netherlands
dc.description.affiliationUnespSão Paulo State Univ, Dept Clin Surg & Anim Reprod, São Paulo, Brazil
dc.format.extent320-325
dc.identifierhttp://dx.doi.org/10.1111/j.1439-0531.2009.01425.x
dc.identifier.citationReproduction In Domestic Animals. Malden: Wiley-blackwell Publishing, Inc, v. 44, p. 320-325, 2009.
dc.identifier.doi10.1111/j.1439-0531.2009.01425.x
dc.identifier.issn0936-6768
dc.identifier.lattes3725971100777730
dc.identifier.urihttp://hdl.handle.net/11449/39744
dc.identifier.wosWOS:000267756400068
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing, Inc
dc.relation.ispartofReproduction in Domestic Animals
dc.relation.ispartofjcr1.422
dc.relation.ispartofsjr0,594
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleEffects of Short-term Hyper- and Hypoprolactinaemia on Hormones of the Pituitary, Gonad and -Thyroid Axis and on Semen Quality in Male Beaglesen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-blackwell Publishing, Inc
dspace.entity.typePublication
unesp.author.lattes3725971100777730
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina Veterinária, Araçatubapt
unesp.departmentClínica, Cirurgia e Reprodução Animal - FMVApt

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