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Semen parameters, fertility and testosterone levels in male rats exposed prenatally to betamethasone

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dc.contributor.authorPiffer, Renata C. [UNESP]
dc.contributor.authorGarcia, Patricia C. [UNESP]
dc.contributor.authorGerardin, Daniela C. C. [UNESP]
dc.contributor.authorKempinas, Wilma G. [UNESP]
dc.contributor.authorPereira, Oduvaldo C. M. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:33:18Z
dc.date.available2014-05-20T13:33:18Z
dc.date.issued2009-01-01
dc.description.abstractThe present study investigated the long-term effects of prenatal betamethasone exposure on sperm quality and count, fertility and plasma testosterone levels in adult male rats. Pregnant rats received 0.1 mg kg(-1) betamethasone on Days 12, 13, 18 and 19 of pregnancy. This treatment impaired sperm quality, sperm production, fertility and plasma testosterone levels in adult male offspring compared to the control group. Thus, the results of the present study indicate that the long-term effects of prenatal betamethasone exposure may be deleterious to offspring. The consequent decrease in testosterone production during adulthood, in association with damaged semen parameters, may explain for the observed decrease in the capacity of adult male offspring to themselves generate viable descendants.en
dc.description.affiliationSão Paulo State Univ UNESP, Botucatu Med Sch, Dept Clin Med, BR-18618000 São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ UNESP, Dept Morphol, Inst Biosci, BR-18618000 São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ UNESP, Dept Pharmacol, Inst Biosci, BR-18618000 São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Botucatu Med Sch, Dept Clin Med, BR-18618000 São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Dept Morphol, Inst Biosci, BR-18618000 São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Dept Pharmacol, Inst Biosci, BR-18618000 São Paulo, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdCNPq: 142388/2004-1
dc.description.sponsorshipIdFAPESP: 06/57038-6
dc.format.extent634-639
dc.identifierhttp://dx.doi.org/10.1071/RD08203
dc.identifier.citationReproduction Fertility and Development. Collingwood: Csiro Publishing, v. 21, n. 5, p. 634-639, 2009.
dc.identifier.doi10.1071/RD08203
dc.identifier.issn1031-3613
dc.identifier.urihttp://hdl.handle.net/11449/11384
dc.identifier.wosWOS:000266406400002
dc.language.isoeng
dc.publisherCSIRO Publishing
dc.relation.ispartofReproduction, Fertility and Development
dc.relation.ispartofjcr2.105
dc.relation.ispartofsjr0,681
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectreproductionen
dc.subjectspermen
dc.titleSemen parameters, fertility and testosterone levels in male rats exposed prenatally to betamethasoneen
dc.typeArtigo
dcterms.licensehttp://www.publish.csiro.au/nid/36.htm
dcterms.rightsHolderCsiro Publishing
dspace.entity.typePublication
unesp.author.orcid0000-0002-2112-5123[4]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
unesp.departmentClínica Médica - FMBpt

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Botucatu - FMB - Faculdade de Medicina