Logo do repositório
 

beta-carotene attenuates the paradoxical effect of tobacco smoke on the mortality of rats after experimental myocardial infarction

dc.contributor.authorPaiva, SAR
dc.contributor.authorNovo, R.
dc.contributor.authorMatsubara, Beatriz Bojikian [UNESP]
dc.contributor.authorMatsubara, Luiz Shiguero [UNESP]
dc.contributor.authorGaiolla, Paula Schmidt Azevedo [UNESP]
dc.contributor.authorMinicucci, Marcos Ferreira [UNESP]
dc.contributor.authorCampana, A. O.
dc.contributor.authorZornoff, Leonardo Antonio Mamede [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:32:52Z
dc.date.available2014-05-20T13:32:52Z
dc.date.issued2005-09-01
dc.description.abstractThe objective of this study was to investigate the effects of exposure to tobacco smoke (ETS) in rats that were or were not supplemented with dietary beta-carotene (BC), on ventricular remodeling and survival after myocardial infarction (MI). Rats (n = 189) were allocated to 4 groups: the control group, n = 45; group BC administered 500 mg/kg diet, n = 49, BC supplemented rats; group ETS, n = 55, rats exposed to tobacco smoke; and group BC+ETS, n = 40. Wistar rats weighing 100 g were administered one of the treatments until they weighed 200 to 250 g (similar to 5 wk). The ETS rats were exposed to cigarette smoke for 30 min 4 times/d, in a chamber connected to a smoking device. After reaching a weight of 200-250 g, rats were subjected to experimental MI (coronary artery occlusion) and mortality rates were determined over the next 105 d. In addition, echocardiographic, isolated heart, morphometrical, and biochemical studies were performed. Mortality data were tested using Kaplan-Meyer curves and other data by 2-way ANOVA. Survival rates were greater in the ETS group (58.2%) than in the control (33.3%) (P = 0.001) and BC+ETS rats (30.0%) (P = 0.007). The groups did not differ in the other comparisons. Left ventricular end-diastolic diameter normalized to body weight was greater and maximal systolic pressures were lower in the ETS groups than in non-ETS groups. Previous exposure to tobacco smoke induced a process of cardiac remodeling after MI. There is a paradoxical protector effect with tobacco smoke exposure, characterized by lower mortality, which is offset by BC supplementation.en
dc.description.affiliationUniv Estadual Paulista, Fac Med Botucatu, Dept Clin Med, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Med Botucatu, Dept Clin Med, Botucatu, SP, Brazil
dc.format.extent2109-2113
dc.identifierhttp://jn.nutrition.org/content/135/9/2109.long
dc.identifier.citationJournal of Nutrition. Bethesda: Amer Society Nutritional Science, v. 135, n. 9, p. 2109-2113, 2005.
dc.identifier.issn0022-3166
dc.identifier.lattes6990977122340795
dc.identifier.lattes6309835137998766
dc.identifier.lattes5016839015394547
dc.identifier.lattes1213140801402647
dc.identifier.lattes7438704034471673
dc.identifier.orcid0000-0002-9831-8820
dc.identifier.orcid0000-0002-5843-6232
dc.identifier.urihttp://hdl.handle.net/11449/11233
dc.identifier.wosWOS:000231780800007
dc.language.isoeng
dc.publisherAmer Society Nutritional Science
dc.relation.ispartofJournal of Nutrition
dc.relation.ispartofjcr4.398
dc.relation.ispartofsjr2,191
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectsmokingpt
dc.subjectventricular remodelingpt
dc.subjectbeta-carotenept
dc.subjectparadoxical effectpt
dc.subjectmyocardial infarctionpt
dc.titlebeta-carotene attenuates the paradoxical effect of tobacco smoke on the mortality of rats after experimental myocardial infarctionen
dc.typeArtigo
dcterms.licensehttp://www.nutrition.org/publications/guidelines-and-policies/permissions/
dcterms.rightsHolderAmer Society Nutritional Science
dspace.entity.typePublication
unesp.author.lattes5016839015394547[7]
unesp.author.lattes6990977122340795
unesp.author.lattes6309835137998766
unesp.author.lattes1213140801402647[5]
unesp.author.lattes7438704034471673
unesp.author.orcid0000-0002-9831-8820[7]
unesp.author.orcid0000-0002-5843-6232[5]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
unesp.departmentClínica Médica - FMBpt

Arquivos

Licença do pacote

Agora exibindo 1 - 1 de 1
Carregando...
Imagem de Miniatura
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição: