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Low protein diet confers resistance to the inhibitory effects of interleukin1 beta on insulin secretion in pancreatic islets

dc.contributor.authorVieira, E. C.
dc.contributor.authorCarneiro, E. M.
dc.contributor.authorLatorraca, M. Q.
dc.contributor.authorDelguingaro-Augusto, V
dc.contributor.authorAmaral, MEC
dc.contributor.authorBosqueiro, JR
dc.contributor.authorBoschero, A. C.
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Mato Grosso (UFMT)
dc.date.accessioned2014-05-20T13:25:39Z
dc.date.available2014-05-20T13:25:39Z
dc.date.issued2001-05-01
dc.description.abstractHigh protein content in the diet during childhood and adolescence has been associated to the onset insulin-dependent diabetes mellitus. We investigated the effect of interleukin-1 beta (IL-I beta) on insulin secretion, glucose metabolism, and nitrite formation by islets isolated from rats fed with normal protein (NP, 17%) or low protein (LP, 6%) after weaning. Pretreatment of islets with IL-1 beta for 1 h or 34 h inhibited the insulin secretion induced by glucose in both groups, but it was less marked in LP than in NP group. Islets from LP rats exhibited a decreased IL-1 beta -induced nitric oxide (NO) production, lower inhibition of D-[(UC)-C-14]-glucose oxidation to (CO2)-C-14, and less pronounced effect of IL-1 beta on alpha -ketoisocaproic acid-induced insulin secretion than NP islets. However, when the islets were stimulated by high concentrations of K+ the inhibitory effect of IL-1 beta on insulin secretion was not different between groups. In conclusion, protein restriction protects beta -cells of the deleterious effect of IL-1 beta, apparently, by decreasing NO production. The lower NO generation in islets from protein deprived rats may be due to increased free fatty acids oxidation and consequent alteration in Ca2+ homeostasis. (C) 2001 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Estadual Campinas, UNICAMP, Inst Biol, Dept Fisiol & Biofis, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Inst Biol, Dept Biol, Bauru, Brazil
dc.description.affiliationUFMT, Fac Engfermagem & Nutr, Dept Nutr & Dietet, Cuiaba, MG, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Inst Biol, Dept Biol, Bauru, Brazil
dc.format.extent285-291
dc.identifierhttp://dx.doi.org/10.1016/S0955-2863(01)00140-1
dc.identifier.citationJournal of Nutritional Biochemistry. New York: Elsevier B.V., v. 12, n. 5, p. 285-291, 2001.
dc.identifier.doi10.1016/S0955-2863(01)00140-1
dc.identifier.issn0955-2863
dc.identifier.lattes2423477869556138
dc.identifier.urihttp://hdl.handle.net/11449/8157
dc.identifier.wosWOS:000169096600005
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Nutritional Biochemistry
dc.relation.ispartofjcr4.414
dc.relation.ispartofsjr1,678
dc.rights.accessRightsAcesso restritopt
dc.sourceWeb of Science
dc.subjectprotein malnutritionpt
dc.subjectpancreatic isletspt
dc.subjectinsulin secretionpt
dc.subjectinterleukin 1 betapt
dc.subjectbeta cellpt
dc.subjectcytokinespt
dc.titleLow protein diet confers resistance to the inhibitory effects of interleukin1 beta on insulin secretion in pancreatic isletsen
dc.typeArtigopt
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
relation.isDepartmentOfPublication2a2301bd-017f-4714-8dbf-068917656539
relation.isDepartmentOfPublication.latestForDiscovery2a2301bd-017f-4714-8dbf-068917656539
relation.isOrgUnitOfPublicationaef1f5df-a00f-45f4-b366-6926b097829b
relation.isOrgUnitOfPublication.latestForDiscoveryaef1f5df-a00f-45f4-b366-6926b097829b
unesp.author.lattes2423477869556138
unesp.author.orcid0000-0003-3829-8570[7]
unesp.author.orcid0000-0001-5128-2202[5]
unesp.author.orcid0000-0001-5367-7427[6]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências, Baurupt
unesp.departmentCiências Biológicas - FCpt

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