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Morphological Changes in the Myotendinous Junction of mdx Mice

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dc.contributor.authorMartinez, Giovana Zerbo [UNESP]
dc.contributor.authorGrillo, Bruna Aléxia Cristofoletti [UNESP]
dc.contributor.authorRocha, Lara Caetano [UNESP]
dc.contributor.authorJacob, Carolina Dos Santos [UNESP]
dc.contributor.authorPimentel Neto, Jurandyr [UNESP]
dc.contributor.authorTomiate, André Neri [UNESP]
dc.contributor.authorBarbosa, Gabriela Klein [UNESP]
dc.contributor.authorWatanabe, Ii-Sei
dc.contributor.authorCiena, Adriano Polican [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2022-04-28T19:43:35Z
dc.date.available2022-04-28T19:43:35Z
dc.date.issued2021-10-17
dc.description.abstractThe myotendinous junction (MTJ) is the interface between muscle and tendon, and it is the main area of force transmission of the locomotor apparatus. Dystrophic processes promote pathological injury which affects the skeletal muscle and can influence the morphology of the MTJ. This study aimed to investigate the adaptations in MTJ morphology of mdx mice in the tibialis anterior muscle. Male mice (n = 24) were divided into Control-C57bl/10 and mdx-C57bl/10mdx (Duchenne muscular dystrophy experimental model). In the mdx group, centralized nuclei with a large area and greater deposition of type III collagen (fibrosis) were observed. Also, shorter sarcomeres and sarcoplasmatic projections of MTJ were observed. We concluded that the adaptations in mdx mice demonstrated extensive impairment in the MTJ region with reduced ultrastructures.en
dc.description.affiliationLaboratory of Morphology and Physical Activity (LAMAF) São Paulo State University (UNESP) Institute of Biosciences (IB), Avenue 24A, n. 1515, SP
dc.description.affiliationDepartment of Anatomy Institute of Biomedical Sciences Iii University of São Paulo (USP)
dc.description.affiliationUnespLaboratory of Morphology and Physical Activity (LAMAF) São Paulo State University (UNESP) Institute of Biosciences (IB), Avenue 24A, n. 1515, SP
dc.format.extent1290-1294
dc.identifierhttp://dx.doi.org/10.1017/S1431927621012496
dc.identifier.citationMicroscopy and Microanalysis, v. 27, n. 5, p. 1290-1294, 2021.
dc.identifier.doi10.1017/S1431927621012496
dc.identifier.issn1435-8115
dc.identifier.issn1431-9276
dc.identifier.scopus2-s2.0-85113186771
dc.identifier.urihttp://hdl.handle.net/11449/222253
dc.language.isoeng
dc.relation.ispartofMicroscopy and Microanalysis
dc.sourceScopus
dc.subjectDuchenne muscular dystrophy
dc.subjectfibrosis
dc.subjectfinger-like process
dc.subjectmuscle degeneration
dc.subjectsarcomere
dc.titleMorphological Changes in the Myotendinous Junction of mdx Miceen
dc.typeArtigo
dspace.entity.typePublication

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