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Effects of methylmercury on male reproductive functions in Wistar rats

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dc.contributor.authorFossato da Silva, Daniela A. [UNESP]
dc.contributor.authorTeixeira, Carla T. [UNESP]
dc.contributor.authorScarano, Wellerson R. [UNESP]
dc.contributor.authorFavareto, Ana Paula A.
dc.contributor.authorFernandez, Carla D. B.
dc.contributor.authorGrotto, Denise
dc.contributor.authorBarbosa, Fernando
dc.contributor.authorKempinas, Wilma de G. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T13:51:58Z
dc.date.available2014-05-20T13:51:58Z
dc.date.issued2011-05-01
dc.description.abstractIn this study we investigated the effects of subacute exposure to methylmercury (MeHg) on male reproductive functions in rats by means of determination of alterations in structural and functional parameters. Adult male Wistar rats received 0, 0.5, 1.0 or 3.0 mg/kg/body weight/day orally, daily MeHg for 14 days. Sperm motility, the relative sperm count and transit time in the caput/corpus epididymis, were all reduced at all doses. The lowest dose increased the number of sperm head abnormalities; daily sperm production was elevated at the intermediate dose; while at the highest dose there was a decrease in serum testosterone levels and a rise in mercury (Hg) content in reproductive organs, liver and kidneys. In conclusion, MeHg exposure produced damages on male reproductive functions which may be attributed, at least in part, to the reduction in serum testosterone levels. These consequences could potentially result in infertility in rats. (C) 2011 Elsevier B.V. All rights reserved.en
dc.description.affiliationUNESP Univ Estadual Paulista, Dept Morphol, Inst Biosci, Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Inst Biol, Grad Program Cellular & Struct Biol, UNICAMP, Campinas, SP, Brazil
dc.description.affiliationUniv São Paulo, Dept Clin Toxicol & Bromatol Anal, BR-14049 Ribeirao Preto, SP, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Dept Morphol, Inst Biosci, Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 07/56458-4
dc.format.extent431-439
dc.identifierhttp://dx.doi.org/10.1016/j.reprotox.2011.01.002
dc.identifier.citationReproductive Toxicology. Oxford: Pergamon-Elsevier B.V. Ltd, v. 31, n. 4, p. 431-439, 2011.
dc.identifier.doi10.1016/j.reprotox.2011.01.002
dc.identifier.issn0890-6238
dc.identifier.urihttp://hdl.handle.net/11449/18569
dc.identifier.wosWOS:000291377200008
dc.language.isoeng
dc.publisherPergamon-Elsevier B.V. Ltd
dc.relation.ispartofReproductive Toxicology
dc.relation.ispartofjcr2.580
dc.relation.ispartofsjr0,846
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectReproductive toxicityen
dc.subjectMethylmercuryen
dc.subjectRaten
dc.subjectTestosteroneen
dc.subjectSpermen
dc.subjectTestisen
dc.subjectEpididymisen
dc.subjectICP-MSen
dc.titleEffects of methylmercury on male reproductive functions in Wistar ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderPergamon-Elsevier B.V. Ltd
dspace.entity.typePublication
unesp.author.orcid0000-0002-6682-2934[3]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.departmentMorfologia - IBBpt

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Botucatu - IBB - Instituto de Biociências