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Preliminary X-ray crystallographic studies of a Lys49-phospholipase A(2) homologue from Bothrops pirajai venom complexed with p-bromophenacyl bromide and alpha-tocopherol inhibitors

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dc.contributor.authorSantos, Juliana I. dos [UNESP]
dc.contributor.authorMarchi-Salvador, Daniela P. [UNESP]
dc.contributor.authorFernandes, Carlos A. H. [UNESP]
dc.contributor.authorSilveira, Lucas B.
dc.contributor.authorSoares, Andreimar M.
dc.contributor.authorFontes, Marcos R. M. [UNESP]
dc.date.accessioned2015-11-17T15:33:14Z
dc.date.available2015-11-17T15:33:14Z
dc.date.issued2007-01-01
dc.description.abstractPrTX-I, a non-catalytic and myotoxic Lys49-PLA(2) from Bothrops pirajai venom has been crystallized alone and in complex with bromophenacyl bromide (BPB), alpha-tocopherol and alpha-tocopherol acetate inhibitors. These crystals have shown to diffract X-rays between 2.34 and 1.65 angstrom resolution. All complexes crystals are isomorphous and belong to the space group P2(1) whereas native PrTX-I crystals belong to the P3(1)21.en
dc.description.affiliationDepartamento de Física e Biofísica Instituto de Biociências UNESP, C. P. 510, CEP 18618-000, Botucatu-SP
dc.description.affiliationUnespDepartamento de Física e Biofísica Instituto de Biociências UNESP, C. P. 510, CEP 18618-000, Botucatu-SP
dc.format.extent698-701
dc.identifierhttp://dx.doi.org/10.2174/092986607781483796
dc.identifier.citationProtein and Peptide Letters, v. 14, n. 7, p. 698-701, 2007.
dc.identifier.doi10.2174/092986607781483796
dc.identifier.issn0929-8665
dc.identifier.scopus2-s2.0-34548669385
dc.identifier.urihttp://hdl.handle.net/11449/130626
dc.identifier.wosWOS:000253577200011
dc.language.isoeng
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofProtein and Peptide Letters
dc.relation.ispartofjcr1.039
dc.relation.ispartofsjr0,429
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectα-tocopherol
dc.subjectBothrops pirajai venom
dc.subjectCrystallization
dc.subjectLys49-phospholipase A2
dc.subjectMyotoxity
dc.subjectp-BPB
dc.subjectP-bromophenacyl bromide
dc.subjectVitamin E
dc.subjectX-ray crystallography
dc.subjectAlpha tocopherol
dc.subjectBromide
dc.subjectEnzyme inhibitor
dc.subjectLysine
dc.subjectPhospholipase A
dc.subjectSnake venom
dc.subjectAnimal
dc.subjectChemical structure
dc.subjectChemistry
dc.subjectProtein conformation
dc.subjectSnake
dc.subjectX ray crystallography
dc.subjectAlpha-Tocopherol
dc.subjectAnimals
dc.subjectBothrops
dc.subjectBromides
dc.subjectCrotalid Venoms
dc.subjectCrystallography, X-Ray
dc.subjectEnzyme Inhibitors
dc.subjectLysine
dc.subjectModels, Molecular
dc.subjectPhospholipases A
dc.subjectProtein Conformation
dc.subjectBothrops pirajai
dc.titlePreliminary X-ray crystallographic studies of a Lys49-phospholipase A(2) homologue from Bothrops pirajai venom complexed with p-bromophenacyl bromide and alpha-tocopherol inhibitorsen
dc.typeArtigo
dcterms.licensehttp://eurekaselect.com/209
dcterms.rightsHolderBentham Science Publ Ltd
dspace.entity.typePublication
unesp.author.orcid0000-0002-4634-6221[6]
unesp.author.orcid0000-0001-6515-6872[3]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.departmentFísica e Biofísica - IBBpt

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