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Antimicrobial effect of intracanal substances

dc.contributor.authorCarreira, Claudia de Moura
dc.contributor.authorFerreira dos Santos, Silvana Soleo
dc.contributor.authorCardoso Jorge, Antonio Olavo [UNESP]
dc.contributor.authorLage-Marques, Jose Luiz
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Taubate
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:27:39Z
dc.date.available2014-05-20T15:27:39Z
dc.date.issued2007-09-01
dc.description.abstractIn some situations, endodontic infections do not respond to therapeutic protocol. In these cases, it is suggested the administration of an alternative intracanal medication that presents a wide spectrum of action and has an in-depth effect on the root canal system. The purpose of this study was to assess the antimicrobial action of ciprofloxacin, metronidazole and polyethylene glycol and natrosol vehicles with different associations and concentrations. The minimum inhibitory concentration (MIC) was determined by using the agar dilution method. The culture media (Muller-Hinton agar) were prepared containing antimicrobial agents at multiple two-fold dilutions of 0.25 to 16 mu g/mL, and with the vehicles at the concentrations of 50, 45, 40, 35, 30 and 25%. Twenty-three microbial strains were selected for the study. Metronidazole was not capable of eliminating any of the tested microorganisms. The association of ciprofloxacin with metronidazole resulted in a reduction of the MIC. The vehicle polyethylene glycol inhibited the growth of 100% of the tested strains, while natrosol inhibited 18% of the strains. Ciprofloxacin formulations with polyethylene glycol presented better effects than those of formulations to which metronidazole was added. It was possible to conclude that ciprofloxacin presented antimicrobial action against all tested bacteria] strains, and its association with metronidazole was synergic. The vehicle polyethylene glycol showed antimicrobial effect and the ciprofloxacin/polyethylene glycol association was the most effective combination for reducing the tested bacteria and yeasts.en
dc.description.affiliationUniv São Paulo, Postgrad Program Dent, São Paulo, Brazil
dc.description.affiliationUniv Taubate, Dept Dent, Postgrad Program Endodont, Taubate, SP, Brazil
dc.description.affiliationSão Paulo State Univ, Sch Dent Sao Jose Campos, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Sch Dent Sao Jose Campos, Sao Jose Dos Campos, SP, Brazil
dc.format.extent453-458
dc.identifierhttp://dx.doi.org/10.1590/S1678-77572007000500015
dc.identifier.citationJournal of Applied Oral Science. Bauru-sp: Univ São Paulo Fac Odontologia Bauru, v. 15, n. 5, p. 453-458, 2007.
dc.identifier.doi10.1590/S1678-77572007000500015
dc.identifier.fileWOS000256794600014.pdf
dc.identifier.issn1678-7757
dc.identifier.lattes0053567153623569
dc.identifier.scieloS1678-77572007000500015
dc.identifier.urihttp://hdl.handle.net/11449/37590
dc.identifier.wosWOS:000256794600014
dc.language.isoeng
dc.publisherUniversidade de São Paulo (USP), Faculdade de Odontologia de Bauru
dc.relation.ispartofJournal of Applied Oral Science
dc.relation.ispartofjcr1.709
dc.relation.ispartofsjr0,645
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectciprofloxacinpt
dc.subjectmetronidazolept
dc.subjectpolyethylene glycolspt
dc.subjectnatrosolpt
dc.subjectendodonticspt
dc.titleAntimicrobial effect of intracanal substancesen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/jaos/iaboutj.htm#003
dcterms.rightsHolderUniv São Paulo Fac Odontologia Bauru
dspace.entity.typePublication
unesp.author.lattes0053567153623569[3]
unesp.author.orcid0000-0002-1747-6158[3]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Ciência e Tecnologia, São José dos Campospt
unesp.departmentBiociências e Diagnóstico Bucal - ICTpt

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