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Transmission analysis of candidate genes for nonsyndromic oral clefts in Brazilian parent-child triads with recurrence

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dc.contributor.authorda Silva, Aline Loureno̧ [UNESP]
dc.contributor.authorRibeiro, Lucilene Arilho [UNESP]
dc.contributor.authorCooper, Margaret E.
dc.contributor.authorMarazita, Mary L.
dc.contributor.authorMoretti-Ferreira, Danilo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversity of Pittsburgh
dc.date.accessioned2014-05-27T11:21:58Z
dc.date.available2014-05-27T11:21:58Z
dc.date.issued2006-09-20
dc.description.abstractCleft lip and/or palate (CL/P) is a major congenital defect with complex etiology, including multiple genetic and environmental factors. Approximately two thirds of the cases are not accompanied by other anomalies and are called nonsyndromic (NS). In the present study, we performed transmission distortion analysis of the MSX1-CA, TGFB3-CA and MTHFR-C677T polymorphisms in 60 parent-child triads, in which the NS-CL/ P affected child had at least one affected parent. No association with genes MSX1 or TGFB3 was found, but the results were suggestive of an association of the MTHFR-C677T polymorphism with NS-CL/P. © 2006 Sociedade Brasileira de Genética.en
dc.description.affiliationUniversidade Estadual Paulista - UNESP, Distrito de Rubiao Junior s/n, 18618-000 Botucatu SP
dc.description.affiliationHospital de Reabilitatiao de Anomalias Craniofaciais Universidade de São Paulo - USP, Bauru, SP
dc.description.affiliationCenter for Craniofacial and Dental Genetics University of Pittsburgh, Pittsburgh, PA
dc.description.affiliationUnespUniversidade Estadual Paulista - UNESP, Distrito de Rubiao Junior s/n, 18618-000 Botucatu SP
dc.format.extent439-442
dc.identifierhttp://dx.doi.org/10.1590/S1415-47572006000300005
dc.identifier.citationGenetics and Molecular Biology, v. 29, n. 3, p. 439-442, 2006.
dc.identifier.doi10.1590/S1415-47572006000300005
dc.identifier.file2-s2.0-33748650083.pdf
dc.identifier.issn1415-4757
dc.identifier.issn1678-4685
dc.identifier.orcid0000-0002-9256-7623
dc.identifier.scieloS1415-47572006000300005
dc.identifier.scopus2-s2.0-33748650083
dc.identifier.urihttp://hdl.handle.net/11449/69093
dc.identifier.wosWOS:000240328500005
dc.language.isoeng
dc.relation.ispartofGenetics and Molecular Biology
dc.relation.ispartofjcr1.493
dc.relation.ispartofsjr0,638
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectCleft lip
dc.subjectCleft palate
dc.subjectOral clefts
dc.subject5,10 methylenetetrahydrofolate reductase (FADH2)
dc.subjectDNA
dc.subjecttranscription factor MSX1
dc.subjecttransforming growth factor beta3
dc.subjectadult
dc.subjectallele
dc.subjectchild
dc.subjectcleft lip
dc.subjectcleft palate
dc.subjectDNA determination
dc.subjectfamily assessment
dc.subjectfemale
dc.subjectgene frequency
dc.subjectgene linkage disequilibrium
dc.subjectgene mapping
dc.subjectgenetic association
dc.subjectgenetic polymorphism
dc.subjectgenetic risk
dc.subjectgenotype
dc.subjectheredity
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectpathophysiology
dc.subjectrisk assessment
dc.subjectsex difference
dc.titleTransmission analysis of candidate genes for nonsyndromic oral clefts in Brazilian parent-child triads with recurrenceen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/gmb/iaboutj.htm
dspace.entity.typePublication
unesp.author.orcid0000-0002-9256-7623[5]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.departmentGenética - IBBpt

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