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Activity of neurons in the preoptic area and their participation in reproductive senescence: preliminary findings

dc.contributor.authorFerreira, Larissa Brazolotto [UNESP]
dc.contributor.authorNicola, Angela Cristina de [UNESP]
dc.contributor.authorAnselmo-Franci, Janete Aparecida
dc.contributor.authorDornelles, Rita Cássia Menegati [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2015-12-07T15:39:09Z
dc.date.available2015-12-07T15:39:09Z
dc.date.issued2015-10-08
dc.description.abstractAlterations in the hypothalamic-pituitary-gonadal axis in females determine the transition from regular to irregular reproductive cycles, with loss of fertility. Stimulation of noradrenergic neurons of the anteroventral periventricular neurons (AVPV) is essential for regular reproductive cycles. Therefore, we examined the activity of neurons of the AVPV and measure the noradrenaline (NE) of acyclic rats, in constant estrus, and compared it with that of cyclic rats in estrus. Female cyclic (4-5months) and acyclic (17-18months) rats were euthanized at 10, 14, and 18h in estrus. Brains were processed for immunoreactivity to antigens related to Fos (FRA) in AVPV, and the NE was determined by HPLC-ED. Plasma concentrations of LH, FSH, E2 and P4 were determined. In the acyclic animals, plasma LH was higher but the FSH was lower. There was decreasing P4 at different times, while the E2 was constant and lower in acyclic rats. FRA-ir expression in AVPV neurons of acyclic rats as well as turnover of NE was higher when compared with cyclic group. The preliminary findings showed increased activity in AVPV neurons in aging contribute to changes in the temporal pattern of neuroendocrine signaling, compromising the accuracy of inhibitory and stimulatory effects, causing irregularity in the estrous cycle and determining reproductive senescence.en
dc.description.affiliationPrograma Multicêntrico de Pós-Graduação em Ciências Fisiológicas, SBFis/UNESP, Univ Estadual Paulista, Araçatuba, São Paulo, Brazil; Laboratory of Endocrine Physiology and Aging, Department of Basic Sciences, Araçatuba Dental School, UNESP - Univ Estadual Paulista, Araçatuba, São Paulo, Brazil.
dc.description.affiliationLaboratory of Neuroendocrinology, School of Dentistry of Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
dc.description.affiliationPrograma Multicêntrico de Pós-Graduação em Ciências Fisiológicas, SBFis/UNESP, Univ Estadual Paulista, Araçatuba, São Paulo, Brazil; Laboratory of Endocrine Physiology and Aging, Department of Basic Sciences, Araçatuba Dental School, UNESP - Univ Estadual Paulista, Araçatuba, São Paulo, Brazil. Electronic address: rcdfisio@foa.unesp.br.
dc.description.affiliationUnespPrograma Multicêntrico de Pós-Graduação em Ciências Fisiológicas, SBFis/UNESP, Univ Estadual Paulista, Araçatuba, São Paulo, Brazil; Laboratory of Endocrine Physiology and Aging, Department of Basic Sciences, Araçatuba Dental School, UNESP - Univ Estadual Paulista, Araçatuba, São Paulo, Brazil.
dc.description.affiliationUnespPrograma Multicêntrico de Pós-Graduação em Ciências Fisiológicas, SBFis/UNESP, Univ Estadual Paulista, Araçatuba, São Paulo, Brazil; Laboratory of Endocrine Physiology and Aging, Department of Basic Sciences, Araçatuba Dental School, UNESP - Univ Estadual Paulista, Araçatuba, São Paulo, Brazil. Electronic address: rcdfisio@foa.unesp.br.
dc.format.extent157-161
dc.identifierhttp://dx.doi.org/10.1016/j.exger.2015.10.003
dc.identifier.citationExperimental Gerontology, v. 72, p. 157-161, 2015.
dc.identifier.doi10.1016/j.exger.2015.10.003
dc.identifier.issn1873-6815
dc.identifier.lattes5435902422784889
dc.identifier.orcid0000-0003-0783-6612
dc.identifier.pubmed26456420
dc.identifier.urihttp://hdl.handle.net/11449/131633
dc.language.isoeng
dc.publisherElsevier B. V.
dc.relation.ispartofExperimental Gerontology
dc.rights.accessRightsAcesso restritopt
dc.sourcePubMed
dc.subjectAcyclicityen
dc.subjectAgingen
dc.subjectNoradrenalineen
dc.subjectReproductive senescenceen
dc.titleActivity of neurons in the preoptic area and their participation in reproductive senescence: preliminary findingsen
dc.typeArtigopt
dcterms.rightsHolderElsevier B. V.
dspace.entity.typePublication
relation.isOrgUnitOfPublication8b3335a4-1163-438a-a0e2-921a46e0380d
relation.isOrgUnitOfPublication.latestForDiscovery8b3335a4-1163-438a-a0e2-921a46e0380d
unesp.author.lattes5435902422784889[4]
unesp.author.orcid0000-0003-0783-6612[4]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araçatubapt
unesp.departmentCiências Básicas - FOApt

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