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Reduction of crotoxin-induced neuromuscular blockade by gamma radiation

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dc.contributor.authorGallacci, M.
dc.contributor.authorNunes, E. C.
dc.contributor.authorMoreira, E. G.
dc.contributor.authorNascimento, N.
dc.contributor.authorRogero, JR
dc.contributor.authorVassilieff, V. S.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInstituto de Pesquisas Energéticas e Nucleares (IPEN)
dc.date.accessioned2014-05-20T13:49:01Z
dc.date.available2014-05-20T13:49:01Z
dc.date.issued1998-06-01
dc.description.abstractA comparative study between crotoxin and gamma irradiated crotoxin was performed on the indirectly evoked twitches and tetani of sciatic nerve-extensor digitorum longus muscle of rats. Crotoxin (3 to 14 mu g/ml) decreased the amplitude of twitches and induced a slight tetanic fade, and irradiated crotoxin did not significantly affect either twitch amplitude or tetanic tension. Since gamma radiation reduced the neurotoxicity of crotoxin it may be useful for the production of anticrotalic serum. (C) 1998 Elsevier B.V. Ltd. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias, Dept Farmacol, Botucatu, SP, Brazil
dc.description.affiliationIPEN, CNEN SP, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biociencias, Dept Farmacol, Botucatu, SP, Brazil
dc.format.extent941-945
dc.identifierhttp://dx.doi.org/10.1016/S0041-0101(97)00105-0
dc.identifier.citationToxicon. Oxford: Pergamon-Elsevier B.V., v. 36, n. 6, p. 941-945, 1998.
dc.identifier.doi10.1016/S0041-0101(97)00105-0
dc.identifier.issn0041-0101
dc.identifier.lattes9353490382598257
dc.identifier.urihttp://hdl.handle.net/11449/17447
dc.identifier.wosWOS:000074184200012
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofToxicon
dc.relation.ispartofjcr2.352
dc.relation.ispartofsjr0,692
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleReduction of crotoxin-induced neuromuscular blockade by gamma radiationen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
unesp.author.lattes9353490382598257
unesp.author.orcid0000-0001-6149-4030[1]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.departmentFarmacologia - IBBpt

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