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Abnormal cell-cycle expression of the proteins p27, mdm2 and cathepsin B in oral squamous-cell carcinoma infected with human papillomavirus

dc.contributor.authorMazon, Renata Cristina
dc.contributor.authorGerbelli, Thais Rovigatti
dc.contributor.authorNeto, Carlos Benatti [UNESP]
dc.contributor.authorBrancini de Oliveira, Maria Rita [UNESP]
dc.contributor.authorDonadi, Eduardo Antonio
dc.contributor.authorGuimaraes Goncalves, Maria Alice
dc.contributor.authorSoares, Edson Garcia
dc.contributor.authorKlay, Carla Patricia
dc.contributor.authorTersariol, Ivarne
dc.contributor.authorPinhal, Maria Aparecida
dc.contributor.authorResende, Luis
dc.contributor.authorSoares, Christiane Pienna [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T13:45:55Z
dc.date.available2014-05-20T13:45:55Z
dc.date.issued2011-01-01
dc.description.abstractSince the role of human papillomavirus (HPV) infection in oral carcinogenesis is still unclear, the purpose of this study was to verify the association between the expression of p27, mdm2 and cathepsin B and by HPV-related oral lesions. Fifty-five oral biopsies were studied and HPV detection and typing (6/11, 16, 18, 31 and 33) were performed using polymerase chain reaction techniques. The distribution p27, mdm2 and cathepsin B was determined by immunohistochemistry. Twenty-one (38%) out of the 55 oral lesions tested positive for HPV, of which 6(33%) were HPV 6/11, 1 (5%) was HPV 16,14 (72%) were HPV 18 and none was HPV 33/31. Among the 55 biopsies, immunopostivity for p27, mdm2 and cathepsin B was observed in 17 (30.9%), 37 (67.2%) and 37 (67.2%), respectively. Among 21 HPV-positive oral lesions, immunopostivity of mdm2, p27 and cathepsin B was found, respectively, in 6 (33%) out of 18 benign lesions (BL), 4(22%) out of 18 potential malignant epithelial lesions (PMEL) and 11(57.9%) out of 19 malignant lesions (ML). High-risk HPV types may be associated with oral carcinoma, by cell-cycle control dysregulation, contributing to oral carcinogenesis and the overexpression of mdm2, p27 and cathepsin B. (C) 2009 Elsevier GmbH. All rights reserved.en
dc.description.affiliationUniv São Paulo State UNESP, Fac Pharmaceut Sci, Dept Clin Anal, Sch Pharmaceut Sci, BR-14801902 São Paulo, Brazil
dc.description.affiliationUniv São Paulo State UNESP, Sch Dent, BR-14801902 São Paulo, Brazil
dc.description.affiliationFed Univ São Paulo State UNIFESP, Fac Med, São Paulo, Brazil
dc.description.affiliationUnespUniv São Paulo State UNESP, Fac Pharmaceut Sci, Dept Clin Anal, Sch Pharmaceut Sci, BR-14801902 São Paulo, Brazil
dc.description.affiliationUnespUniv São Paulo State UNESP, Sch Dent, BR-14801902 São Paulo, Brazil
dc.description.sponsorshipFundação para o Desenvolvimento da UNESP (FUNDUNESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent109-116
dc.identifierhttp://dx.doi.org/10.1016/j.acthis.2009.08.008
dc.identifier.citationActa Histochemica. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 113, n. 2, p. 109-116, 2011.
dc.identifier.doi10.1016/j.acthis.2009.08.008
dc.identifier.issn0065-1281
dc.identifier.lattes1768025290373669
dc.identifier.orcid0000-0003-1740-7360
dc.identifier.urihttp://hdl.handle.net/11449/16203
dc.identifier.wosWOS:000288888900006
dc.language.isoeng
dc.publisherElsevier Gmbh, Urban & Fischer Verlag
dc.relation.ispartofActa Histochemica
dc.relation.ispartofjcr1.652
dc.relation.ispartofsjr0,661
dc.rights.accessRightsAcesso restritopt
dc.sourceWeb of Science
dc.subjectHPVen
dc.subjectOral canceren
dc.subjectp27en
dc.subjectmd m2en
dc.subjectCathepsin Ben
dc.subjectImmunohistochemistryen
dc.titleAbnormal cell-cycle expression of the proteins p27, mdm2 and cathepsin B in oral squamous-cell carcinoma infected with human papillomavirusen
dc.typeArtigopt
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier Gmbh, Urban & Fischer Verlag
dspace.entity.typePublication
relation.isDepartmentOfPublicationa83d26d6-5383-42e4-bb3c-2678a6ddc144
relation.isDepartmentOfPublication.latestForDiscoverya83d26d6-5383-42e4-bb3c-2678a6ddc144
relation.isOrgUnitOfPublication95697b0b-8977-4af6-88d5-c29c80b5ee92
relation.isOrgUnitOfPublication.latestForDiscovery95697b0b-8977-4af6-88d5-c29c80b5ee92
unesp.author.lattes1768025290373669[12]
unesp.author.orcid0000-0002-9457-9601[5]
unesp.author.orcid0000-0003-1740-7360[12]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentAnálises Clínicas - FCFpt

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