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Ruthenium(II) complexes with hydroxypyridinecarboxylates: screening potential metallodrugs against Mycobacterium tuberculosis

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dc.contributor.authorBarbosa, Marilia I. F.
dc.contributor.authorCorrea, Rodrigo S.
dc.contributor.authorPozzi, Lucas V.
dc.contributor.authorLopes, Erica de O. [UNESP]
dc.contributor.authorPavan, Fernando R. [UNESP]
dc.contributor.authorLeite, Clarice Q. F. [UNESP]
dc.contributor.authorEllena, Javier
dc.contributor.authorMachado, Sergio de P.
dc.contributor.authorVon Poelhsitz, Gustavo
dc.contributor.authorBatista, Alzir A.
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionUniversidade Federal de Uberlândia (UFU)
dc.date.accessioned2015-10-21T20:56:26Z
dc.date.available2015-10-21T20:56:26Z
dc.date.issued2015-01-08
dc.description.abstractThree promising antimycobacterium tuberculosis ruthenium(II) complexes with the deprotonated ligands 2-hydroxynicotinic acid (2-OHnicH), 6-hydroxynicotinic acid (6-OHnicH) and 3-hydroxypicolinic acid (3-OHpicH) were synthesized and characterized. Structural analysis revealed three different coordination modes depending of the hydroxypyridinecarboxylate ligand. In the complex [Ru(2-OHnic)(dppb)(bipy)PF6 (1), the 2-OHnic anion is coordinated by the O,O-chelating mode (via carboxylate group and phenolate oxygen), in the Ru(6-OHnic)(dppb)(bipy)]PF6 (2) a O-O chelation by the carboxylate group is observed for the 6-OHnic ligand and for the complex [Ru(3-OHpic)(dppb)(bipy))PF6 (3) a N,O-chelating mode (via carboxylate) occurs to the 3-OHpic anion. The compounds were evaluated for activity against Mycobacterium tuberculosis H(37)Rv ATCC 27294 using Resazurin Microtitre Assay (REMA) plate method and cytotoxicity in VERO CCL-81 cell line. All the synthesized compounds exhibited good antimycobacterial activity and a completely lack of cytotoxicity activity, indicating a good selectivity index. (C) 2014 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Ciencias Biol, Fac Ciencias Farmaceut, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Fis Sao Carlos, BR-13560970 Sao Carlos, SP, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, Inst Quim, BR-21941590 Rio De Janeiro, RJ, Brazil
dc.description.affiliationUniv Fed Uberlandia, Inst Quim, BR-38400902 Uberlandia, MG, Brazil
dc.description.affiliationUnespDepartamento de Ciências Biológicas, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista, CEP: 14800-900, Araraquara (SP) Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.description.sponsorshipIdFAPESP: 2013/26559-4
dc.format.extent376-382
dc.identifierhttp://www.sciencedirect.com/science/article/pii/S0277538714005889
dc.identifier.citationPolyhedron. Oxford: Pergamon-elsevier Science Ltd, v. 85, p. 376-382, 2015.
dc.identifier.doi10.1016/j.poly.2014.08.057
dc.identifier.issn0277-5387
dc.identifier.urihttp://hdl.handle.net/11449/129367
dc.identifier.wosWOS:000347582900047
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPolyhedron
dc.relation.ispartofjcr2.067
dc.relation.ispartofsjr0,472
dc.rights.accessRightsAcesso abertopt
dc.sourceWeb of Science
dc.subjectMycobacterium tuberculosisen
dc.subjectCytotoxicityen
dc.subjectRuthenium(II) complexesen
dc.subjectMetallodrugsen
dc.subjectHydroxypyridinecarboxylatesen
dc.titleRuthenium(II) complexes with hydroxypyridinecarboxylates: screening potential metallodrugs against Mycobacterium tuberculosisen
dc.typeArtigopt
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
relation.isDepartmentOfPublication5004bcab-94af-4939-b980-091ae9d0a19e
relation.isDepartmentOfPublication.latestForDiscovery5004bcab-94af-4939-b980-091ae9d0a19e
relation.isOrgUnitOfPublication95697b0b-8977-4af6-88d5-c29c80b5ee92
relation.isOrgUnitOfPublication.latestForDiscovery95697b0b-8977-4af6-88d5-c29c80b5ee92
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentCiências Biológicas - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas