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Publicação:
Renal effects of Bunodosoma caissarum crude extract: Prostaglandin and endothelin involvement

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dc.contributor.authorMartins, René Duarte
dc.contributor.authorJorge, Roberta Jeane Bezerra
dc.contributor.authorAlves, Renata de Sousa
dc.contributor.authorSilva Neto, Antônio Gomes da
dc.contributor.authorBarbosa, Paulo Sergio F.
dc.contributor.authorCosta Martins, Alice Maria
dc.contributor.authorToyama, Marcos H. [UNESP]
dc.contributor.authorMonteiro, Helena Serra Azul
dc.contributor.institutionUniversidade Federal de Pernambuco (UFPE)
dc.contributor.institutionFederal University of Ceará
dc.contributor.institutionState University of Ceará
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:14:03Z
dc.date.available2018-12-11T17:14:03Z
dc.date.issued2017-11-01
dc.description.abstractSea anemones contain a variety of interesting biologically active compounds, including some potent toxins. PLA2 from Bunodosoma caissarum, a sea anemone endemic in the Brazilian southern coast, has shown renal alterations on isolated kidney. The aim of this study was to evaluate the renal and vascular effects of B. caissarum crude extract (BcE) on isolated perfused kidney and arteriolar mesenteric bed, as well the involvement of prostaglandins and endothelin. BcE did not show any effect on arteriolar mesenteric bed, but increased perfusion pressure, renal vascular resistance, urinary flow, glomerular filtration rate and decreased the percentage of sodium tubular transport on isolated perfused kidney. Indomethacin blocked the renal effects induced by BcE and tezosentan only partially blocked these effects. These results demonstrate the effects of BcE on kidney in situ, suggesting the involvement of prostaglandins and endothelin.en
dc.description.affiliationDepartment of Nutrition Federal University of Pernambuco CAV
dc.description.affiliationDepartment of Clinical and Toxicological Analyses Federal University of Ceará
dc.description.affiliationDepartment of Physiology and Pharmacology Institute of Biomedicine and Clinical Research Unit Federal University of Ceará
dc.description.affiliationVeterinary Faculty State University of Ceará
dc.description.affiliationSão Vicente Unit Campus of Litoral Paulista Paulista State University (UNESP)
dc.description.affiliationUnespSão Vicente Unit Campus of Litoral Paulista Paulista State University (UNESP)
dc.format.extent78-81
dc.identifierhttp://dx.doi.org/10.1016/j.toxicon.2017.08.019
dc.identifier.citationToxicon, v. 138, p. 78-81.
dc.identifier.doi10.1016/j.toxicon.2017.08.019
dc.identifier.file2-s2.0-85027840671.pdf
dc.identifier.issn1879-3150
dc.identifier.issn0041-0101
dc.identifier.scopus2-s2.0-85027840671
dc.identifier.urihttp://hdl.handle.net/11449/175060
dc.language.isoeng
dc.relation.ispartofToxicon
dc.relation.ispartofsjr0,692
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectBunodosoma caissarum
dc.subjectEndothelin
dc.subjectEnvenomation
dc.subjectIsolated perfused kidney
dc.subjectProstaglandin
dc.subjectSea anemone
dc.titleRenal effects of Bunodosoma caissarum crude extract: Prostaglandin and endothelin involvementen
dc.typeArtigo
dspace.entity.typePublication
unesp.author.orcid0000-0002-2703-4302[2]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, São Vicentept
unesp.departmentCiências Biológicas - IBCLPpt

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São Vicente - IBCLP - Instituto de Biociências