Publicação: Stress-induced subsensitivity to catecholamines depends on the estrous cycle
Carregando...
Data
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Natl Research Council Canada
Tipo
Artigo
Direito de acesso
Acesso restrito
Resumo
In this article we compare how sensitivity to the chronotropic effect of noradrenaline and adrenaline of right atria isolated from female rats is modified after repeated swimming or foot-shock stress, under the influence of the estrous cycle. Right atria from stressed female rats sacrificed at diestrus were subsensitive to both catecholamines, irrespective of the stressor agent. However, although subsensitivity to noradrenaline was of similar intensity, subsensitivity to adrenaline was more pronounced in right atria from foot shock stressed rats as opposed to swimming-stressed rats. Identical stress protocols did not induce any alteration in atrial sensitivity to catecholamines when the stressed female rats were sacrificed at estrus. We conclude that the stress reaction concerning the mediation of cardiac chronotropism by catecholamines is related to the severity of the stressor agent and is strongly influenced by the estrous cycle.
Descrição
Palavras-chave
foot-shock stress, swimming stress, female rats, noradrenaline, adrenaline, estrus, diestrus
Idioma
Inglês
Como citar
Canadian Journal of Physiology and Pharmacology. Ottawa: Natl Research Council Canada, v. 74, n. 6, p. 663-669, 1996.