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Impairment of adult male reproductive function in rats exposed to ethanol since puberty

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dc.contributor.authorOliva, Samara U.
dc.contributor.authorMessias, Alessandra G.
dc.contributor.authorSilva, Daniela A. F.
dc.contributor.authorPereira, Oduvaldo C. M.
dc.contributor.authorGerardin, Daniela C. C.
dc.contributor.authorKempinas, Wilma G.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:49:01Z
dc.date.available2014-05-20T13:49:01Z
dc.date.issued2006-11-01
dc.description.abstractThe objective of this work was to evaluate reproductive function in adult male rats exposed to ethanol since puberty. Male Wistar rats, 50 days old, received a liquid diet with 36% of the daily calories derived from ethanol or an isocaloric control diet for 55 days. The ethanol treatment impaired sexual behavior and only 22% of these rats reached ejaculation. The fertility of ethanol-treated animals was significantly reduced, mainly after natural mating. Serum testosterone levels, daily sperm production and sperm count in the epididymis were also significantly diminished after ethanol treatment, associated with an acceleration of the sperm transit time in the cauda epididymidis, decrease in sperm motility and increased percentage of abnormal shaped sperm cells. The results showed that chronic consumption of ethanol beginning at puberty impairs the reproductive function of adult male rats. (c) 2006 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, Dept Morfol, Inst Biociencias, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Inst Biociencias, Dept Farmacol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Morfol, Inst Biociencias, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, Inst Biociencias, Dept Farmacol, BR-18618000 Botucatu, SP, Brazil
dc.format.extent599-605
dc.identifierhttp://dx.doi.org/10.1016/j.reprotox.2006.04.017
dc.identifier.citationReproductive Toxicology. Oxford: Pergamon-Elsevier B.V., v. 22, n. 4, p. 599-605, 2006.
dc.identifier.doi10.1016/j.reprotox.2006.04.017
dc.identifier.issn0890-6238
dc.identifier.urihttp://hdl.handle.net/11449/17455
dc.identifier.wosWOS:000241622800009
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofReproductive Toxicology
dc.relation.ispartofjcr2.580
dc.relation.ispartofsjr0,846
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectethanolpt
dc.subjectmale reproductive toxicologypt
dc.subjectWistar ratpt
dc.subjectepididymispt
dc.subjectspermpt
dc.subjectfertilitypt
dc.subjectpubertypt
dc.subjectin utero artificial inseminationpt
dc.titleImpairment of adult male reproductive function in rats exposed to ethanol since pubertyen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.departmentFarmacologia - IBBpt
unesp.departmentMorfologia - IBBpt

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