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National Brazilian survey on the outcomes of hepatitis c retreatment in patients non-responders to direct antiviral agents

dc.contributor.authorFerraz, Maria Lúcia Gomes
dc.contributor.authorPiccoli, Leonora de Zorzi
dc.contributor.authorRezende, Rosamar
dc.contributor.authorBorba, Luiz Augusto
dc.contributor.authorJunior, Alcindo Pissaia
dc.contributor.authorCheinquer, Hugo
dc.contributor.authorSilva, Giovanni Faria [UNESP]
dc.contributor.authorFerreira, Paulo Roberto Abrão
dc.contributor.authorVillela-Nogueira, Cristiane Alves
dc.contributor.authorMazo, Daniel Ferraz
dc.contributor.authorSouza, Fernanda Fernandes
dc.contributor.authorCodes, Liana
dc.contributor.authorIvantes, Claudia Alexandra Pontes
dc.contributor.authorGomide, Geisa Perez Medina
dc.contributor.authorPereira, Gustavo Henrique Santos
dc.contributor.authorPessôa, Mário Guimarães
dc.contributor.authorFrança, Alex Vianey Callado
dc.contributor.authorPinto, Arlene dos Santos
dc.contributor.authorTeixeira, Rosângela
dc.contributor.authorBittencourt, Paulo Lisboa
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionServiço Municipal de Infectologia de Caxias do Sul
dc.contributor.institutionCentro de Referência em Especialidades
dc.contributor.institutionHospital das Clínicas da Faculdade de Medicina de Ribeirão Preto
dc.contributor.institutionAmbulatório de Hepatites Virais
dc.contributor.institutionHospital Nossa Senhora das Graças
dc.contributor.institutionUniversidade Federal do Rio Grande do Sul
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionHospital Português
dc.contributor.institutionEscola Bahiana de Medicina e Saúde Pública
dc.contributor.institutionPrefeitura de Curitiba
dc.contributor.institutionUniversidade Federal do Triângulo Mineiro
dc.contributor.institutionServiço de Gastroenterologia e Hepatologia
dc.contributor.institutionUniversidade Federal de Sergipe (UFS)
dc.contributor.institutionPrograma de Pós-graduação em Medicina Tropical
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.date.accessioned2023-03-01T21:16:50Z
dc.date.available2023-03-01T21:16:50Z
dc.date.issued2022-07-01
dc.description.abstractBackground and aims: Treatment of hepatitis C with direct antiviral agents (DAA) is associated with almost 95% of sustained virological response. However, some patients need retreatment. In Brazil, it should be done according to the Ministry of Health guidelines, frequently updated to include newly available drugs. This study aimed to conduct a national survey about the characteristics and outcomes of retreatment of hepatitis C in previously non-responders to DAAs. Patients and methods: Institutions from all over the country were invited to participate in a national registry for retreatment, including information about clinical and epidemiological characteristics of the patients, type and outcomes of retreatment regimens. Only patients previously treated with interferon-free regimens were included. Results: As previous treatments the distribution was: SOF/DCV (56%), SOF/SIM (22%), 3D (11%), SOF/LED (6%) and SOF/RBV (5%). For retreatment the most frequently used drugs were SOF/GP (46%), SOF/DCV (23%) and SOF/VEL (11%). From 159 patients retreated, 132/159 (83%) had complete information in the registry and among them only seven patients were non-responders (SVR of 94.6%). All retreatments were well tolerated, without any serious adverse events or interruptions. Conclusion: The retreatment of patients previously non-responders to DAAs was associated with high rate of SVR in this sample of Brazilian patients. This finding allows us to conclude that the retreatment options available in the public health system in Brazil are effective and safe and are an important component of the strategy of elimination of hepatitis C in our country.en
dc.description.affiliationUniversidade Federal de São Paulo Disciplina de Gastroenterologia, SP
dc.description.affiliationServiço Municipal de Infectologia de Caxias do Sul, RS
dc.description.affiliationSecretária Municipal de Saúde de Ribeirão Preto Centro de Referência em Especialidades, SP
dc.description.affiliationUniversidade São Paulo Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, SP
dc.description.affiliationPrefeitura Municipal de Criciúma Ambulatório de Hepatites Virais, SC
dc.description.affiliationHospital Nossa Senhora das Graças, PR
dc.description.affiliationUniversidade Federal do Rio Grande do Sul, RS
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho Faculdade de Medicina de Botucatu, SP
dc.description.affiliationUniversidade Federal de São Paulo Disciplina de Infectologia, SP
dc.description.affiliationUniversidade Federal do Rio de Janeiro Faculdade de Medicina, RJ
dc.description.affiliationUniversidade Estadual de Campinas Faculdade de Ciências Médicas Divisão de Gastroenterologia do Departamento de Clínica Médica, SP
dc.description.affiliationUniversidade de São Paulo Faculdade de Medicina Hospital das Clínicas Divisão de Gastroenterologia e Hepatologia, SP
dc.description.affiliationHospital Português, BA
dc.description.affiliationEscola Bahiana de Medicina e Saúde Pública, BA
dc.description.affiliationSecretaria Municipal de Saúde Prefeitura de Curitiba, PR
dc.description.affiliationUniversidade Federal do Triângulo Mineiro, MG
dc.description.affiliationHospital Federal de Bonsucesso (Ministério da Saúde) Serviço de Gastroenterologia e Hepatologia, RJ
dc.description.affiliationUniversidade de São Paulo Faculdade de Medicina, SP
dc.description.affiliationUniversidade Federal de Sergipe, SE
dc.description.affiliationFundação de Medicina Tropical do Amazonas Programa de Pós-graduação em Medicina Tropical, AM
dc.description.affiliationUniversidade Federal de Minas Gerais, MG
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho Faculdade de Medicina de Botucatu, SP
dc.identifierhttp://dx.doi.org/10.1016/j.bjid.2022.102388
dc.identifier.citationBrazilian Journal of Infectious Diseases, v. 26, n. 4, 2022.
dc.identifier.doi10.1016/j.bjid.2022.102388
dc.identifier.issn1678-4391
dc.identifier.issn1413-8670
dc.identifier.scopus2-s2.0-85135397013
dc.identifier.urihttp://hdl.handle.net/11449/241688
dc.language.isoeng
dc.relation.ispartofBrazilian Journal of Infectious Diseases
dc.sourceScopus
dc.subjectDAA
dc.subjectHepatitis C
dc.subjectRetreatment
dc.subjectSustained virological response
dc.titleNational Brazilian survey on the outcomes of hepatitis c retreatment in patients non-responders to direct antiviral agentsen
dc.typeArtigo
dspace.entity.typePublication
unesp.author.orcid0000-0001-8992-8494[1]
unesp.author.orcid0000-0001-9573-9438[5]
unesp.author.orcid0000-0003-4858-2778[8]
unesp.author.orcid0000-0003-1355-2368[9]
unesp.author.orcid0000-0002-2164-2630 0000-0002-2164-2630[10]
unesp.author.orcid0000-0002-2369-7686[11]
unesp.author.orcid0000-0002-6657-5515[14]

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