Publicação: National Brazilian survey on the outcomes of hepatitis c retreatment in patients non-responders to direct antiviral agents
dc.contributor.author | Ferraz, Maria Lúcia Gomes | |
dc.contributor.author | Piccoli, Leonora de Zorzi | |
dc.contributor.author | Rezende, Rosamar | |
dc.contributor.author | Borba, Luiz Augusto | |
dc.contributor.author | Junior, Alcindo Pissaia | |
dc.contributor.author | Cheinquer, Hugo | |
dc.contributor.author | Silva, Giovanni Faria [UNESP] | |
dc.contributor.author | Ferreira, Paulo Roberto Abrão | |
dc.contributor.author | Villela-Nogueira, Cristiane Alves | |
dc.contributor.author | Mazo, Daniel Ferraz | |
dc.contributor.author | Souza, Fernanda Fernandes | |
dc.contributor.author | Codes, Liana | |
dc.contributor.author | Ivantes, Claudia Alexandra Pontes | |
dc.contributor.author | Gomide, Geisa Perez Medina | |
dc.contributor.author | Pereira, Gustavo Henrique Santos | |
dc.contributor.author | Pessôa, Mário Guimarães | |
dc.contributor.author | França, Alex Vianey Callado | |
dc.contributor.author | Pinto, Arlene dos Santos | |
dc.contributor.author | Teixeira, Rosângela | |
dc.contributor.author | Bittencourt, Paulo Lisboa | |
dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | |
dc.contributor.institution | Serviço Municipal de Infectologia de Caxias do Sul | |
dc.contributor.institution | Centro de Referência em Especialidades | |
dc.contributor.institution | Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto | |
dc.contributor.institution | Ambulatório de Hepatites Virais | |
dc.contributor.institution | Hospital Nossa Senhora das Graças | |
dc.contributor.institution | Universidade Federal do Rio Grande do Sul | |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | |
dc.contributor.institution | Universidade Federal do Rio de Janeiro (UFRJ) | |
dc.contributor.institution | Universidade Estadual de Campinas (UNICAMP) | |
dc.contributor.institution | Universidade de São Paulo (USP) | |
dc.contributor.institution | Hospital Português | |
dc.contributor.institution | Escola Bahiana de Medicina e Saúde Pública | |
dc.contributor.institution | Prefeitura de Curitiba | |
dc.contributor.institution | Universidade Federal do Triângulo Mineiro | |
dc.contributor.institution | Serviço de Gastroenterologia e Hepatologia | |
dc.contributor.institution | Universidade Federal de Sergipe (UFS) | |
dc.contributor.institution | Programa de Pós-graduação em Medicina Tropical | |
dc.contributor.institution | Universidade Federal de Minas Gerais (UFMG) | |
dc.date.accessioned | 2023-03-01T21:16:50Z | |
dc.date.available | 2023-03-01T21:16:50Z | |
dc.date.issued | 2022-07-01 | |
dc.description.abstract | Background and aims: Treatment of hepatitis C with direct antiviral agents (DAA) is associated with almost 95% of sustained virological response. However, some patients need retreatment. In Brazil, it should be done according to the Ministry of Health guidelines, frequently updated to include newly available drugs. This study aimed to conduct a national survey about the characteristics and outcomes of retreatment of hepatitis C in previously non-responders to DAAs. Patients and methods: Institutions from all over the country were invited to participate in a national registry for retreatment, including information about clinical and epidemiological characteristics of the patients, type and outcomes of retreatment regimens. Only patients previously treated with interferon-free regimens were included. Results: As previous treatments the distribution was: SOF/DCV (56%), SOF/SIM (22%), 3D (11%), SOF/LED (6%) and SOF/RBV (5%). For retreatment the most frequently used drugs were SOF/GP (46%), SOF/DCV (23%) and SOF/VEL (11%). From 159 patients retreated, 132/159 (83%) had complete information in the registry and among them only seven patients were non-responders (SVR of 94.6%). All retreatments were well tolerated, without any serious adverse events or interruptions. Conclusion: The retreatment of patients previously non-responders to DAAs was associated with high rate of SVR in this sample of Brazilian patients. This finding allows us to conclude that the retreatment options available in the public health system in Brazil are effective and safe and are an important component of the strategy of elimination of hepatitis C in our country. | en |
dc.description.affiliation | Universidade Federal de São Paulo Disciplina de Gastroenterologia, SP | |
dc.description.affiliation | Serviço Municipal de Infectologia de Caxias do Sul, RS | |
dc.description.affiliation | Secretária Municipal de Saúde de Ribeirão Preto Centro de Referência em Especialidades, SP | |
dc.description.affiliation | Universidade São Paulo Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, SP | |
dc.description.affiliation | Prefeitura Municipal de Criciúma Ambulatório de Hepatites Virais, SC | |
dc.description.affiliation | Hospital Nossa Senhora das Graças, PR | |
dc.description.affiliation | Universidade Federal do Rio Grande do Sul, RS | |
dc.description.affiliation | Universidade Estadual Paulista Júlio de Mesquita Filho Faculdade de Medicina de Botucatu, SP | |
dc.description.affiliation | Universidade Federal de São Paulo Disciplina de Infectologia, SP | |
dc.description.affiliation | Universidade Federal do Rio de Janeiro Faculdade de Medicina, RJ | |
dc.description.affiliation | Universidade Estadual de Campinas Faculdade de Ciências Médicas Divisão de Gastroenterologia do Departamento de Clínica Médica, SP | |
dc.description.affiliation | Universidade de São Paulo Faculdade de Medicina Hospital das Clínicas Divisão de Gastroenterologia e Hepatologia, SP | |
dc.description.affiliation | Hospital Português, BA | |
dc.description.affiliation | Escola Bahiana de Medicina e Saúde Pública, BA | |
dc.description.affiliation | Secretaria Municipal de Saúde Prefeitura de Curitiba, PR | |
dc.description.affiliation | Universidade Federal do Triângulo Mineiro, MG | |
dc.description.affiliation | Hospital Federal de Bonsucesso (Ministério da Saúde) Serviço de Gastroenterologia e Hepatologia, RJ | |
dc.description.affiliation | Universidade de São Paulo Faculdade de Medicina, SP | |
dc.description.affiliation | Universidade Federal de Sergipe, SE | |
dc.description.affiliation | Fundação de Medicina Tropical do Amazonas Programa de Pós-graduação em Medicina Tropical, AM | |
dc.description.affiliation | Universidade Federal de Minas Gerais, MG | |
dc.description.affiliationUnesp | Universidade Estadual Paulista Júlio de Mesquita Filho Faculdade de Medicina de Botucatu, SP | |
dc.identifier | http://dx.doi.org/10.1016/j.bjid.2022.102388 | |
dc.identifier.citation | Brazilian Journal of Infectious Diseases, v. 26, n. 4, 2022. | |
dc.identifier.doi | 10.1016/j.bjid.2022.102388 | |
dc.identifier.issn | 1678-4391 | |
dc.identifier.issn | 1413-8670 | |
dc.identifier.scopus | 2-s2.0-85135397013 | |
dc.identifier.uri | http://hdl.handle.net/11449/241688 | |
dc.language.iso | eng | |
dc.relation.ispartof | Brazilian Journal of Infectious Diseases | |
dc.source | Scopus | |
dc.subject | DAA | |
dc.subject | Hepatitis C | |
dc.subject | Retreatment | |
dc.subject | Sustained virological response | |
dc.title | National Brazilian survey on the outcomes of hepatitis c retreatment in patients non-responders to direct antiviral agents | en |
dc.type | Artigo | |
dspace.entity.type | Publication | |
unesp.author.orcid | 0000-0001-8992-8494[1] | |
unesp.author.orcid | 0000-0001-9573-9438[5] | |
unesp.author.orcid | 0000-0003-4858-2778[8] | |
unesp.author.orcid | 0000-0003-1355-2368[9] | |
unesp.author.orcid | 0000-0002-2164-2630 0000-0002-2164-2630[10] | |
unesp.author.orcid | 0000-0002-2369-7686[11] | |
unesp.author.orcid | 0000-0002-6657-5515[14] |