Logotipo do repositório
 

Publicação:
Oxytocin effects on osteoblastic differentiation of Bone Marrow Mesenchymal Stem Cells from adult and aging female Wistar rats

Página do item simplificado
dc.contributor.authorSantos, Leandro Figueiredo [UNESP]
dc.contributor.authorSingulani, Monique Patricio [UNESP]
dc.contributor.authorStringhetta-Garcia, Camila Tami [UNESP]
dc.contributor.authorOliveira, Sandra Helena Penha de [UNESP]
dc.contributor.authorChaves-Neto, Antonio Hernandes [UNESP]
dc.contributor.authorDornelles, Rita Cássia Menegati [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-06T16:51:46Z
dc.date.available2019-10-06T16:51:46Z
dc.date.issued2018-11-01
dc.description.abstractRecently, it has been suggested that oxytocin (OT) might play a role in the control of bone remodeling and in bone health of young and adult females. The purpose of this study was to evaluate the effect of osteogenic medium (OM) plus OT (OM + OT; 100 nmol/L) on osteoblastic differentiation of bone marrow mesenchymal stem cells (BMMSCs) from cyclic adult (12 months old) and acyclic aging (24 months old) female Wistar rats. After 14 days, OM + OT increased the oxytocin and oxytocin receptor in the BMMSCs from animals of both age groups relative to OM controls. Alkaline phosphatase activity was higher in the OM + OT than OM group in BMMSCs from 24-month-old female rats. OM + OT improved osteogenic differentiation, observed by anticipated mineralization and increased gene expression of bone morphogenetic protein 2, bone sialoprotein, osteopontin and osteocalcin in both aged relative to OM controls. These findings suggest a role for OT as an adjuvant to induce osteoblastic differentiation of BMMSCs from aged female rat.en
dc.description.affiliationPrograma de Pós-Graduação Multicêntrico em Ciências Fisiológicas Unesp-SBFis
dc.description.affiliationSão Paulo State University (UNESP), School of Dentistry, Department of Basic Sciences
dc.description.affiliationUnespPrograma de Pós-Graduação Multicêntrico em Ciências Fisiológicas Unesp-SBFis
dc.description.affiliationUnespSão Paulo State University (UNESP), School of Dentistry, Department of Basic Sciences
dc.description.sponsorshipUniversidade Estadual Paulista
dc.description.sponsorshipIdUniversidade Estadual Paulista: 2011/15501-0
dc.format.extent58-63
dc.identifierhttp://dx.doi.org/10.1016/j.exger.2018.09.023
dc.identifier.citationExperimental Gerontology, v. 113, p. 58-63.
dc.identifier.doi10.1016/j.exger.2018.09.023
dc.identifier.issn1873-6815
dc.identifier.issn0531-5565
dc.identifier.lattes5435902422784889
dc.identifier.orcid0000-0003-0783-6612
dc.identifier.scopus2-s2.0-85054165617
dc.identifier.urihttp://hdl.handle.net/11449/189775
dc.language.isoeng
dc.relation.ispartofExperimental Gerontology
dc.rights.accessRightsAcesso abertopt
dc.sourceScopus
dc.subjectAging
dc.subjectBone marrow
dc.subjectOsteoblast
dc.subjectOxytocin
dc.subjectRat
dc.titleOxytocin effects on osteoblastic differentiation of Bone Marrow Mesenchymal Stem Cells from adult and aging female Wistar ratsen
dc.typeArtigopt
dspace.entity.typePublication
relation.isOrgUnitOfPublication8b3335a4-1163-438a-a0e2-921a46e0380d
relation.isOrgUnitOfPublication.latestForDiscovery8b3335a4-1163-438a-a0e2-921a46e0380d
unesp.author.lattes1743697225702984[5]
unesp.author.lattes5435902422784889[6]
unesp.author.orcid0000-0001-6481-5506[5]
unesp.author.orcid0000-0003-0783-6612[6]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araçatubapt
unesp.departmentCiências Básicas - FOApt

Arquivos

Coleções

Araçatuba - FOA - Faculdade de Odontologia