Activation of 5-HT2C (but not 5-HT1A) receptors in the amygdala enhances fear-induced antinociception: Blockade with local 5-HT2C antagonist or systemic fluoxetine
dc.contributor.author | Tavares, Lígia Renata Rodrigues [UNESP] | |
dc.contributor.author | Baptista-de-Souza, Daniela | |
dc.contributor.author | Canto-de-Souza, Azair [UNESP] | |
dc.contributor.institution | Universidade Federal de São Carlos (UFSCar) | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Neuroscience and Behavioral Institute-IneC | |
dc.date.accessioned | 2018-12-11T16:52:40Z | |
dc.date.available | 2018-12-11T16:52:40Z | |
dc.date.issued | 2018-06-01 | |
dc.description.abstract | It is well-known that the exposure of rodents to threatening environments [e.g., the open arm of the elevated-plus maze (EPM)] elicits pain inhibition. Systemic and/or intracerebral [e.g., periaqueductal gray matter, amygdala) injections of antiaversive drugs [e.g., serotonin (5-HT) ligands, selective serotonin reuptake inhibitors (SSRIs)] have been used to change EPM-open arm confinement induced antinociception (OAA). Here, we investigated (i) the role of the 5-HT1A and 5-HT2C receptors located in the amygdaloid complex on OAA as well as (ii) the effects of systemic pretreatment with fluoxetine (an SSRI) on the effects of intra-amygdala injections of 8-OH-DPAT (a 5-HT1A agonist) or MK-212 (a 5-HT2C agonist) on nociception in mice confined to the open arm or enclosed arm of the EPM. Nociception was assessed by the writhing test. Intra-amygdala injections of 8-OH-DPAT (10 nmol) or MK-212 (0.63 nmol) produced a pronociceptive effect and intensified OAA, respectively. Fluoxetine (2.5 mg/kg, intraperitoneally) did not change 8-OH-DPAT effects on nociception but antagonized the enhancement of the OAA produced by MK-212. Interestingly, prior injection of SB 242084 (a selective 5-HT2C antagonist) into the amygdala also blocked the MK-212 effects on OAA. These results indicate that 5-HT may facilitate nociception and intensify OAA, respectively, at 5-HT1A and 5-HT2C receptors located in the amygdala of mice. The impairment produced by systemic fluoxetine on the OAA enhancement provoked by intra-amygdala MK-212 suggests that this type of fear-induced antinociception may be modulated by SSRIs. | en |
dc.description.affiliation | Psychobiology Group Department of Psychology/CECH- Federal University of São Carlos-UFSCar | |
dc.description.affiliation | Joint Graduate Program in Physiological Sciences UFSCar/UNESP | |
dc.description.affiliation | Neuroscience and Behavioral Institute-IneC | |
dc.description.affiliation | Program in Psychology UFSCar | |
dc.description.affiliationUnesp | Joint Graduate Program in Physiological Sciences UFSCar/UNESP | |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description.sponsorshipId | CAPES: 482356/2013-8 | |
dc.description.sponsorshipId | FAPESP: 2009/17938-6 | |
dc.description.sponsorshipId | CNPq: 309201/2015-2 | |
dc.format.extent | 376-385 | |
dc.identifier | http://dx.doi.org/10.1016/j.neuropharm.2018.03.008 | |
dc.identifier.citation | Neuropharmacology, v. 135, p. 376-385. | |
dc.identifier.doi | 10.1016/j.neuropharm.2018.03.008 | |
dc.identifier.file | 2-s2.0-85044634255.pdf | |
dc.identifier.issn | 1873-7064 | |
dc.identifier.issn | 0028-3908 | |
dc.identifier.scopus | 2-s2.0-85044634255 | |
dc.identifier.uri | http://hdl.handle.net/11449/170848 | |
dc.language.iso | eng | |
dc.relation.ispartof | Neuropharmacology | |
dc.relation.ispartofsjr | 2,043 | |
dc.rights.accessRights | Acesso aberto | |
dc.source | Scopus | |
dc.subject | 5-HT1A and 5-HT2C receptors | |
dc.subject | Amygdala | |
dc.subject | Antinociception | |
dc.subject | Elevated plus maze | |
dc.subject | Fluoxetine | |
dc.subject | Mice | |
dc.title | Activation of 5-HT2C (but not 5-HT1A) receptors in the amygdala enhances fear-induced antinociception: Blockade with local 5-HT2C antagonist or systemic fluoxetine | en |
dc.type | Artigo | |
dspace.entity.type | Publication |
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