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Influence of chitosan-tripolyphosphate nanoparticles on thermosensitive polymeric hydrogels: structural organization, drug release mechanisms and cytotoxicity

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dc.contributor.authorFreitas Mariano, Kelli C.
dc.contributor.authorMonteiro do Nascimento, Monica H.
dc.contributor.authorQuerobino, Samyr M.
dc.contributor.authorRamos Campos, Estefania [UNESP]
dc.contributor.authorOliveira, Jhones L. de [UNESP]
dc.contributor.authorYokaichiya, Fabiano
dc.contributor.authorFranco, Margareth K. K. D.
dc.contributor.authorAlberto-Silva, Carlos
dc.contributor.authorPaula, Eneida de
dc.contributor.authorLombello, Christiane B.
dc.contributor.authorLima, Renata de
dc.contributor.authorFraceto, Leonardo F. [UNESP]
dc.contributor.authorAraujo, Daniele R. de
dc.contributor.institutionUniversidade Federal do ABC (UFABC)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionHelmholtz Zentrum Berlin Mat
dc.contributor.institutionNucl & Energy Res Inst
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniv Sorocaba
dc.date.accessioned2019-10-04T12:37:28Z
dc.date.available2019-10-04T12:37:28Z
dc.date.issued2019-04-04
dc.description.abstractChitosan-tripolyphosphate (CS-TPP) nanoparticles containing naproxen (NPX) were dispersed in poloxamer (PL) as unique (PL407) or binary (PL407-PL403) systems. Nanoparticles presented diameter of similar to 250 nm and zeta potential of similar to 35 mV with drug loading and encapsulation efficiency of 98.4 +/- 0.3% and 36.9 +/- 0.12%, respectively. NPX-CS-TPP shifted the sol-gel transition and micellization temperatures. PL407-PL403 systems presented G ' > G '' compared to PL407. SAXS patterns revealed transitions from lamellar to hexagonal phase organizations with low drug release rates, in the presence of CS-TPP nanoparticles. NPX-CS-TPP-PL407 induced lower cytotoxicity compared to PL407-PL403 in fibroblasts and osteoblasts, making them promising systems for intra-articular delivery. [GRAPHICS] .en
dc.description.affiliationFed Univ ABC, Human & Nat Sci Ctr, Santo Andre, SP, Brazil
dc.description.affiliationState Univ Julio de Mesquita Filho, Dept Environm Engn, Sorocaba, SP, Brazil
dc.description.affiliationHelmholtz Zentrum Berlin Mat, Dept Quantum Phenomena Novel Mat, Berlin, Germany
dc.description.affiliationNucl & Energy Res Inst, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Dept Biochem & Tissue Biol, Inst Biol, Campinas, SP, Brazil
dc.description.affiliationFed Univ ABC, Engn Modelling & Appl Social Sci Ctr, Santo Andre, SP, Brazil
dc.description.affiliationUniv Sorocaba, Dept Biotechnol, Sorocaba, Brazil
dc.description.affiliationUnespState Univ Julio de Mesquita Filho, Dept Environm Engn, Sorocaba, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundacao de Amparoa Pesquisa do Estado de Sao Paulo
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFundacao de Amparoa Pesquisa do Estado de Sao Paulo: FAPESP 2014/26200-9
dc.description.sponsorshipIdFundacao de Amparoa Pesquisa do Estado de Sao Paulo: 2014/14457-5
dc.description.sponsorshipIdFundacao de Amparoa Pesquisa do Estado de Sao Paulo: 2014/12653-1
dc.description.sponsorshipIdCNPq: CNPq 309207/2016-9
dc.description.sponsorshipIdCNPq: 402838/2016-5
dc.format.extent12
dc.identifierhttp://dx.doi.org/10.1080/00914037.2019.1596909
dc.identifier.citationInternational Journal Of Polymeric Materials And Polymeric Biomaterials. Oslo: Taylor & Francis As, 12 p., 2019.
dc.identifier.doi10.1080/00914037.2019.1596909
dc.identifier.issn0091-4037
dc.identifier.urihttp://hdl.handle.net/11449/185677
dc.identifier.wosWOS:000466625400001
dc.language.isoeng
dc.publisherTaylor & Francis As
dc.relation.ispartofInternational Journal Of Polymeric Materials And Polymeric Biomaterials
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectArthritis
dc.subjectchitosan nanoparticles
dc.subjecthydrogels
dc.subjectnaproxen
dc.subjectpoloxamer
dc.titleInfluence of chitosan-tripolyphosphate nanoparticles on thermosensitive polymeric hydrogels: structural organization, drug release mechanisms and cytotoxicityen
dc.typeArtigo
dcterms.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dcterms.rightsHolderTaylor & Francis As
dspace.entity.typePublication
unesp.author.orcid0000-0003-4504-5723[9]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Ciência e Tecnologia, Sorocabapt
unesp.departmentEngenharia Ambiental - ICTSpt

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Sorocaba - ICTS - Instituto de Ciência e Tecnologia