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The small nuclear ribonucleoprotein U1A interacts with NS5 from yellow fever virus

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dc.contributor.authorBronzoni, Roberta V. M.
dc.contributor.authorMadrid, Maria C. F. S.
dc.contributor.authorDuarte, Danilo V. B.
dc.contributor.authorPellegrini, Vanessa O. A. [UNESP]
dc.contributor.authorPacca, Carolina C. [UNESP]
dc.contributor.authorCarmo, Ana C. V. [UNESP]
dc.contributor.authorZanelli, Cleslei Fernando [UNESP]
dc.contributor.authorValentini, Sandro Roberto [UNESP]
dc.contributor.authorSantacruz-Perez, Carolina
dc.contributor.authorBarbosa, Joao A. R. G.
dc.contributor.authorLutz, Carol S.
dc.contributor.authorRahal, Paula [UNESP]
dc.contributor.authorNogueira, Mauricio L.
dc.contributor.institutionFac Med Rio Preto
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionCtr Biol Mol Estrutural
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Med & Dent New Jersey
dc.date.accessioned2014-05-20T14:00:30Z
dc.date.available2014-05-20T14:00:30Z
dc.date.issued2011-06-01
dc.description.abstractThe flavivirus NS5 protein is one of the most important proteins of the replication complex, and cellular proteins can interact with it. This study shows for the first time that the yellow fever virus (YFV) NS5 protein is able to interact with U1A, a protein involved in splicing and polyadenylation. We confirmed this interaction by GST-pulldown assay and by co-immunoprecipitation in YFV-infected cells. A region between amino acids 368 and 448 was identified as the site of interaction of the NS5 protein with U1A. This region was conserved among some flaviviruses of medical importance. The implications of this interaction for flavivirus replication are discussed.en
dc.description.affiliationFac Med Rio Preto, Lab Pesquisa Viirol, BR-15090000 Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationFac Med Rio Preto, Lab Pesquisa Viirol, Dept Doencas Dermatol Infecciosas & Parasitarias, BR-15090000 Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias Letras & Ciencias Exatas, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Ciencias Biol, Fac Ciencias Farmaceut, BR-14801902 Araraquara, Brazil
dc.description.affiliationCtr Biol Mol Estrutural, Lab Nacl Luz, BR-6192 Campinas, SP, Brazil
dc.description.affiliationUniv São Paulo, Dept Microbiol, Inst Ciencias Biomed 2, BR-05508900 São Paulo, Brazil
dc.description.affiliationUniv Med & Dent New Jersey, Dept Biochem & Mol Biol, New Jersey Med Sch, Newark, NJ 07103 USA
dc.description.affiliationUniv Med & Dent New Jersey, Grad Sch Biomed Sci, Newark, NJ 07103 USA
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biociencias Letras & Ciencias Exatas, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Ciencias Biol, Fac Ciencias Farmaceut, BR-14801902 Araraquara, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 2004/11098
dc.description.sponsorshipIdFAPESP: 2005/03260-7
dc.description.sponsorshipIdCNPq: 473613/2007-7
dc.description.sponsorshipIdCNPq: 566289/2008-3
dc.format.extent931-938
dc.identifierhttp://dx.doi.org/10.1007/s00705-011-0927-x
dc.identifier.citationArchives of Virology. Wien: Springer Wien, v. 156, n. 6, p. 931-938, 2011.
dc.identifier.doi10.1007/s00705-011-0927-x
dc.identifier.issn0304-8608
dc.identifier.lattes5333250355049814
dc.identifier.lattes7991082362671212
dc.identifier.lattes1525665408900195
dc.identifier.orcid0000-0001-5693-6148
dc.identifier.orcid0000-0001-7831-1149
dc.identifier.urihttp://hdl.handle.net/11449/21401
dc.identifier.wosWOS:000291056700001
dc.language.isoeng
dc.publisherSpringer Wien
dc.relation.ispartofArchives of Virology
dc.relation.ispartofjcr2.160
dc.relation.ispartofsjr0,973
dc.rights.accessRightsAcesso restritopt
dc.sourceWeb of Science
dc.titleThe small nuclear ribonucleoprotein U1A interacts with NS5 from yellow fever virusen
dc.typeArtigopt
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer Wien
dspace.entity.typePublication
relation.isDepartmentOfPublication5004bcab-94af-4939-b980-091ae9d0a19e
relation.isDepartmentOfPublication.latestForDiscovery5004bcab-94af-4939-b980-091ae9d0a19e
relation.isOrgUnitOfPublication95697b0b-8977-4af6-88d5-c29c80b5ee92
relation.isOrgUnitOfPublication.latestForDiscovery95697b0b-8977-4af6-88d5-c29c80b5ee92
unesp.author.lattes5333250355049814
unesp.author.lattes7991082362671212[12]
unesp.author.lattes1525665408900195[7]
unesp.author.orcid0000-0003-1102-2419[13]
unesp.author.orcid0000-0002-0534-481X[10]
unesp.author.orcid0000-0002-9403-5284[1]
unesp.author.orcid0000-0001-5693-6148[12]
unesp.author.orcid0000-0001-7831-1149[7]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentCiências Biológicas - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas