Publicação:
The rate of force generation by the myocardium is not influenced by afterload

dc.contributor.authorFioretto, J.R.
dc.contributor.authorOkoshi, M.P. [UNESP]
dc.contributor.authorOkoshi, Katashi [UNESP]
dc.contributor.authorCicogna, A.C. [UNESP]
dc.contributor.authorBonatto, R.C.
dc.contributor.authorPadovani, C.R. [UNESP]
dc.contributor.authorTucci, P.J.F. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:11:30Z
dc.date.available2014-05-20T15:11:30Z
dc.date.issued1997-12-01
dc.description.abstractThe influence of afterload on the rate of force generation by the myocardium was investigated using two types of preparations: the in situ dog heart (dP/dt) and isolated papillary muscle of rats (dT/dt). Thirteen anesthetized, mechanically ventilated and thoracotomized dogs were submitted to pharmacological autonomic blockade (3.0 mg/kg oxprenolol plus 0.5 mg/kg atropine). A reservoir connected to the left atrium permitted the control of left ventricular end-diastolic pressure (LVEDP). A mechanical constriction of the descending thoracic aorta allowed to increase the systolic pressure in two steps of 20 mmHg (conditions H1 and H2) above control values (condition C). After arterial pressure elevations (systolic pressure C: 119 ± 8.1; H1: 142 ± 7.9; H2 166 ± 7.7 mmHg; P<0.01), there were no significant differences in heart rate (C: 125 ± 13.9; H1: 125 ± 13.5; H2: 123 ± 14.1 bpm; P>0.05) or LVEDP (C: 6.2 ± 2.48; H1: 6.3 ± 2.43; H2: 6.1 ± 2.51 mmHg; P>0.05). The values of dP/dt did not change after each elevation of arterial pressure (C: 3,068 ± 1,057; H1: 3,112 ± 996; H2: 3,086 ± 980 mmHg/s; P>0.05). In isolated rat papillary muscle, an afterload corresponding to 50% and 75% of the maximal developed tension did not alter the values of the maximum rate of tension development (100%: 78 ± 13; 75%: 80 ± 13; 50%: 79 ± 11 g mm-2 s-1, P>0.05). The results show that the rise in afterload per se does not cause changes in dP/dt or dT/dten
dc.description.affiliationA01
dc.description.affiliationUniversidade Estadual Paulista
dc.description.affiliationUnespUniversidade Estadual Paulista
dc.format.extent1471-1477
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X1997001200015
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 30, n. 12, p. 1471-1477, 1997.
dc.identifier.doi10.1590/S0100-879X1997001200015
dc.identifier.fileS0100-879X1997001200015.pdf
dc.identifier.issn0100-879X
dc.identifier.lattes4463138671998432
dc.identifier.lattes1590971576309420
dc.identifier.lattes9418970103564137
dc.identifier.lattes0246391303241376
dc.identifier.orcid0000-0002-0648-876X
dc.identifier.scieloS0100-879X1997001200015
dc.identifier.urihttp://hdl.handle.net/11449/28054
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica (ABRADIC)
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.relation.ispartofjcr1.492
dc.rights.accessRightsAcesso aberto
dc.sourceSciELO
dc.subjectventricular functionen
dc.subjectafterloaden
dc.subjectdP/dten
dc.subjectdT/dten
dc.subjectpapillary muscleen
dc.subjectisometric contractionsen
dc.titleThe rate of force generation by the myocardium is not influenced by afterloaden
dc.typeArtigo
dspace.entity.typePublication
unesp.author.lattes4463138671998432
unesp.author.lattes1590971576309420
unesp.author.lattes0246391303241376[5]
unesp.author.lattes9418970103564137[4]
unesp.author.lattes8727897080522289[6]
unesp.author.orcid0000-0002-4402-6523[4]
unesp.author.orcid0000-0002-7719-9682[6]
unesp.author.orcid0000-0002-0648-876X[5]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
unesp.departmentClínica Médica - FMBpt

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