ADIPOQ genotypes and haplotypes, circulating adiponectin levels and responsiveness to antihypertensive therapy in preeclampsia
| dc.contributor.author | Pereira, Daniela Alves [UNESP] | |
| dc.contributor.author | de Castro, Ricardo N F | |
| dc.contributor.author | Palei, Ana C | |
| dc.contributor.author | Cavalli, Ricardo C | |
| dc.contributor.author | Sandrim, Valéria Cristina [UNESP] | |
| dc.contributor.author | Luizon, Marcelo R | |
| dc.date.accessioned | 2026-06-30T17:49:31Z | |
| dc.date.issued | 2025-09-22 | |
| dc.description.abstract | AIMS: <AbstractText Label="AIMS" NlmCategory="UNASSIGNED">We compared plasma adiponectin levels between patients with preeclampsia (PE) classified as responsive and nonresponsive to antihypertensive therapy; Moreover, we examined whether <i>ADIPOQ</i> SNPs rs17300539, rs266729,rs2241766, and rs1501299 and their haplotypes are associated with responsiveness to antihypertensive therapy, and whether they affect plasma adiponectin levels in 215 pregnant women with PE.</AbstractText> PATIENTS & METHODS: <AbstractText Label="PATIENTS & METHODS" NlmCategory="UNASSIGNED">Genotypes for <i>ADIPOQ</i> SNPs were determined using TaqMan allelic discrimination assays, and circulating adiponectin concentrations were measured by ELISA.</AbstractText> RESULTS: <AbstractText Label="RESULTS" NlmCategory="UNASSIGNED">Patients with PE classified as nonresponsive to antihypertensive therapy showed higher plasma adiponectin levels than responsive patients. The TG genotype of the rs2241766 SNP was more frequent in responsive patients with PE when compared to nonresponsive patients. Nonresponsive patients with PE carrying specific genotypes of the <i>ADIPOQ</i> SNPs rs17300539 (GG or GA+AA), rs266729 (CC), rs2241766(TT), and rs1501299 (GT+TT), respectively, as well as the 'G,C,T,G' and 'G,C,T,T' haplotypes showed higher plasma adiponectin levels than responsive patients with PE carrying the same genotypes/haplotypes.</AbstractText> CONCLUSIONS: <AbstractText Label="CONCLUSIONS" NlmCategory="UNASSIGNED">Nonresponsive patients with PE showed higher plasma adiponectin levels than responsive patients, the TG genotype of the rs2241766 SNP was more frequent in the responsive patients with PE when compared to nonresponsive patients. Genotypes of rs17300539, rs266729, rs2241766, and rs1501299 SNPs and haplotypes may affect adiponectin levels in patients with PE classified as nonresponsive to antihypertensive therapy.</AbstractText> | |
| dc.description.affiliation | Department of Genetics, Ecology and Evolution, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil | |
| dc.description.affiliation | Department of Biophysics and Pharmacology, Institute of Biosciences, Universidade Estadual Paulista (UNESP), Botucatu, Brazil | |
| dc.description.affiliation | Department of Biology, Federal Center for Technological Education of Minas Gerais (CEFET-MG), Belo Horizonte, Brazil | |
| dc.description.affiliation | Department of Surgery, University of Mississippi Medical Center, Jackson, MS, USA | |
| dc.description.affiliation | Department of Gynecology and Obstetrics, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil | |
| dc.description.affiliationUnesp | Department of Biophysics and Pharmacology, Institute of Biosciences, Universidade Estadual Paulista (UNESP), Botucatu, Brazil | |
| dc.identifier | https://app.dimensions.ai/details/publication/pub.1193850552 | |
| dc.identifier.dimensions | pub.1193850552 | |
| dc.identifier.doi | 10.1080/14622416.2025.2572286 | |
| dc.identifier.issn | 1462-2416 | |
| dc.identifier.issn | 1744-8042 | |
| dc.identifier.orcid | 0000-0001-5491-6709 | |
| dc.identifier.orcid | 0000-0002-2669-5301 | |
| dc.identifier.orcid | 0000-0001-5010-4914 | |
| dc.identifier.orcid | 0000-0002-6168-7470 | |
| dc.identifier.orcid | 0000-0002-8331-3525 | |
| dc.identifier.pmcid | PMC12667679 | |
| dc.identifier.pmid | 41077737 | |
| dc.identifier.uri | https://hdl.handle.net/11449/326927 | |
| dc.publisher | Taylor & Francis | |
| dc.relation.ispartof | Pharmacogenomics; n. 13-14; v. 26; p. 475-484 | |
| dc.rights.accessRights | Acesso restrito | pt |
| dc.rights.sourceRights | closed | |
| dc.source | Dimensions | |
| dc.title | ADIPOQ genotypes and haplotypes, circulating adiponectin levels and responsiveness to antihypertensive therapy in preeclampsia | |
| dc.type | Artigo | pt |
| dspace.entity.type | Publication | |
| relation.isOrgUnitOfPublication | ab63624f-c491-4ac7-bd2c-767f17ac838d | |
| relation.isOrgUnitOfPublication.latestForDiscovery | ab63624f-c491-4ac7-bd2c-767f17ac838d | |
| unesp.campus | Universidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatu | pt |