Transgenic lettuce seedlings carrying hepatitis B virus antigen HBsAg
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Date
Authors
Advisor
Coadvisor
Graduate program
Undergraduate course
Journal Title
Journal ISSN
Volume Title
Publisher
Brazilian Society of Infectious Diseases
Type
Article
Access right
Acesso aberto
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Abstract
The obtainment of transgenic edible plants carrying recombinant antigens is a desired issue in search for economic alternatives viewing vaccine production. Here we report a strategy for genetic transformation of lettuce plants (Lactuca sativa L.) using the surface antigen HBsAg of hepatitis B virus. Transgenic lettuce seedlings were obtained through the application of a regulated balance of plant growth regulators. Genetic transformation process was acquired by cocultivation of cotyledons with Agrobacterium tumefaciens harboring the recombinant plasmid. It is the first description of a lettuce Brazilian variety Vitória de Verão genetically modified.
Description
Keywords
Edible vaccine, Hepatitis B, Oral immunization, Recombinant antigen, Transgenic plants
Language
English
Citation
Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 12, n. 6, p. 469-471, 2008.
