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Trypanocidal tetrahydrofuran lignans from Peperomia blanda

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dc.contributor.authorFelippe, Lidiane Gaspareto [UNESP]
dc.contributor.authorBaldoqui, Debora Cristina [UNESP]
dc.contributor.authorKato, Massuo Jorge
dc.contributor.authorBolzani, Vanderlan da Silva [UNESP]
dc.contributor.authorGuimaraes, Elsie Franklin
dc.contributor.authorCicarelli, Regina Maria Barreto [UNESP]
dc.contributor.authorFurlan, Maysa [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionInst Pesquisas Jardim Rio Janeiro
dc.date.accessioned2014-05-20T14:20:03Z
dc.date.available2014-05-20T14:20:03Z
dc.date.issued2008-01-01
dc.description.abstractFive tetrahydrofuran lignans and two known flavones were isolated from the aerial parts of Peperomia blanda. The structures of the isolated lignans were elucidated by interpretation of their spectroscopic data, including by gHMQC and gHMBC. The relative and absolute configurations of the isolates were determined from NOESY interactions and optical properties, respectively. Four of the lignans were diastercomeric whilst one was of mixed biosynthetic origin. All but one of the lignans exhibited high in vitro trypanocidal activity when assayed against epimastigotes of Trypanosoma cruzi strain Y. (C) 2007 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, Inst Quim, BR-14800 Araraquara, SP, Brazil
dc.description.affiliationUniv São Paulo, Inst Quim, BR-05599 São Paulo, Brazil
dc.description.affiliationInst Pesquisas Jardim Rio Janeiro, Rio de Janeiro, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias Farmaceut, BR-14801 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim, BR-14800 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias Farmaceut, BR-14801 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 03/11524-9
dc.description.sponsorshipIdFAPESP: 05/57042-0
dc.format.extent445-450
dc.identifierhttp://dx.doi.org/10.1016/j.phytochem.2007.08.012
dc.identifier.citationPhytochemistry. Oxford: Pergamon-Elsevier B.V. Ltd, v. 69, n. 2, p. 445-450, 2008.
dc.identifier.doi10.1016/j.phytochem.2007.08.012
dc.identifier.issn0031-9422
dc.identifier.lattes4484083685251673
dc.identifier.lattes1308042794786872
dc.identifier.urihttp://hdl.handle.net/11449/26019
dc.identifier.wosWOS:000253267300018
dc.language.isoeng
dc.publisherPergamon-Elsevier B.V. Ltd
dc.relation.ispartofPhytochemistry
dc.relation.ispartofjcr3.186
dc.relation.ispartofsjr1,048
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectPeperomia blandaen
dc.subjectPiperaceaeen
dc.subjecttetrahydrofuran lignansen
dc.subjectstructural elucidationen
dc.subjecttrypanocidal activityen
dc.titleTrypanocidal tetrahydrofuran lignans from Peperomia blandaen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderPergamon-Elsevier B.V. Ltd
dspace.entity.typePublication
unesp.author.lattes4484083685251673
unesp.author.lattes1308042794786872
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentCiências Biológicas - FCFpt
unesp.departmentQuímica Orgânica - IQARpt

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Araraquara - IQAR - Instituto de Química
Araraquara - FCF - Faculdade de Ciências Farmacêuticas