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Natural rubber latex: Development and in vitro characterization of a future transdermal patch for enuresis treatment

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dc.contributor.authorBarros, Natan Roberto de [UNESP]
dc.contributor.authorRomeiro Miranda, Matheus Carlos [UNESP]
dc.contributor.authorBorges, Felipe Azevedo [UNESP]
dc.contributor.authorPadua Gemeinder, Jose Lucio [UNESP]
dc.contributor.authorMendonca, Ricardo Jose de
dc.contributor.authorCilli, Eduardo Maffud [UNESP]
dc.contributor.authorHerculano, Rondinelli Donizetti [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUFTM ICBN
dc.date.accessioned2018-11-29T03:50:30Z
dc.date.available2018-11-29T03:50:30Z
dc.date.issued2017-01-01
dc.description.abstractEnuresis affects up to 20% of children of 5 years old, enuretic children present arginine vasopressin secretion deficiency, compared to normal children. To keep the level of antidiuretic hormone in the body, the aim of this work was to develop natural rubber latex membranes loaded with desmopressin peptide and characterize its in vitro release. Results demonstrated that 60% of desmopressin incorporated in natural latex was released up to 96 h. Furthermore, hemolysis tests showed no detectable disturbance of the red blood cell membranes. Based on the results, it was possible to conclude that natural latex membranes are able to load desmopressin.en
dc.description.affiliationSao Paulo State Univ, Chem Inst, 55 Prof Francisco Degni St, BR-14800060 Araraquara, SP, Brazil
dc.description.affiliationSao Paulo State Univ, Sch Pharmaceut Sci, Araraquara, Brazil
dc.description.affiliationUFTM ICBN, Biochem Sect, Uberaba, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Chem Inst, 55 Prof Francisco Degni St, BR-14800060 Araraquara, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Sch Pharmaceut Sci, Araraquara, Brazil
dc.format.extent871-876
dc.identifierhttp://dx.doi.org/10.1080/00914037.2017.1280795
dc.identifier.citationInternational Journal Of Polymeric Materials And Polymeric Biomaterials. Oslo: Taylor & Francis As, v. 66, n. 17, p. 871-876, 2017.
dc.identifier.doi10.1080/00914037.2017.1280795
dc.identifier.fileWOS000416503400002.pdf
dc.identifier.issn0091-4037
dc.identifier.urihttp://hdl.handle.net/11449/165901
dc.identifier.wosWOS:000416503400002
dc.language.isoeng
dc.publisherTaylor & Francis As
dc.relation.ispartofInternational Journal Of Polymeric Materials And Polymeric Biomaterials
dc.relation.ispartofsjr0,489
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectBiomaterial
dc.subjectdesmopressin
dc.subjectenuresis
dc.subjectnatural rubber latex
dc.subjectsustained release
dc.titleNatural rubber latex: Development and in vitro characterization of a future transdermal patch for enuresis treatmenten
dc.typeArtigo
dcterms.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dcterms.rightsHolderTaylor & Francis As
dspace.entity.typePublication
unesp.author.orcid0000-0002-4767-0904[6]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.departmentCiências Biológicas - FCLASpt
unesp.departmentBioquímica e Tecnologia - IQpt

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Araraquara - IQAR - Instituto de Química
Assis - FCLAS - Faculdade de Ciências e Letras