Publicação: Anti-inflammatory drug design by molecular hybridization approach
dc.contributor.author | Bosquesi, Priscila Longhin [UNESP] | |
dc.contributor.author | Melo, Tais Regina Ferreira [UNESP] | |
dc.contributor.author | Vizioli, Ednir de Oliveira [UNESP] | |
dc.contributor.author | Santos, Jean Leandro dos [UNESP] | |
dc.contributor.author | Chung, Man Chin [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2016-01-28T16:56:31Z | |
dc.date.available | 2016-01-28T16:56:31Z | |
dc.date.issued | 2011 | |
dc.description.abstract | The design of new drugs with better physiochemical properties, adequateabsorption, distribution, metabolism, and excretion, effective pharmacologic potency andlacking toxicity remains is a challenge. Inflammation is the initial trigger of severaldifferent diseases, such as Alzheimer s disease, asthma, atherosclerosis, colitis, rheumatoidarthritis, depression, cancer; and disorders such as obesity and sexual dysfunction.Although inflammation is not the direct cause of these disorders, inflammatory processesoften increase related pain and suffering. New anti-inflammatory drugs developed usingmolecular hybridization techniques to obtain multiple-ligand drugs can act at one or multipletargets, allowing for synergic action and minimizing toxicity. This work is a review of newanti-inflammatory drugs developed using the molecular modification approach. | en |
dc.description.affiliation | Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Faculdade de Ciências Farmacêuticas de Araraquara (FCFAR), Departamento de Fármacos e Medicamentos, Rodovia Araraquara-Jaú, km 1, Campus Ville, CEP 14801902, Araraquara, SP, Brasil | |
dc.description.affiliationUnesp | Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Faculdade de Ciências Farmacêuticas de Araraquara (FCFAR), Departamento de Fármacos e Medicamentos, Rodovia Araraquara-Jaú, km 1, Campus Ville, CEP 14801902, Araraquara, SP, Brasil | |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description.sponsorship | Conselho Nacional de Pesquisa (CNPq) | |
dc.description.sponsorshipId | FAPESP: 2010/12495-6 | |
dc.description.sponsorshipId | FAPESP: 2010/50330-9 | |
dc.description.sponsorshipId | CNPq: 308157/2010-9 | |
dc.format.extent | 1450-1474 | |
dc.identifier | http://dx.doi.org/10.3390/ph4111450 | |
dc.identifier.citation | Pharmaceuticals, v. 4, p. 1450-1474, 2011. | |
dc.identifier.doi | 10.3390/ph4111450 | |
dc.identifier.file | ISSN1424-8247-2011-04-1450-1474.pdf | |
dc.identifier.issn | 1424-8247 | |
dc.identifier.lattes | 4083068210623663 | |
dc.identifier.lattes | 3204277043366119 | |
dc.identifier.lattes | 5435899068903487 | |
dc.identifier.lattes | 9734333607975413 | |
dc.identifier.lattes | 5737933639516944 | |
dc.identifier.orcid | 0000-0003-4141-0455 | |
dc.identifier.uri | http://hdl.handle.net/11449/133761 | |
dc.language.iso | eng | |
dc.relation.ispartof | Pharmaceuticals | |
dc.relation.ispartofsjr | 1,293 | |
dc.rights.accessRights | Acesso aberto | pt |
dc.source | Currículo Lattes | |
dc.subject | Anti-inflammatory | en |
dc.subject | Hybridization | en |
dc.subject | Multiple-ligands | en |
dc.subject | Mutual prodrug | en |
dc.title | Anti-inflammatory drug design by molecular hybridization approach | en |
dc.type | Artigo | pt |
dspace.entity.type | Publication | |
relation.isDepartmentOfPublication | e214da1b-9929-4ae9-b8fd-655e9bfeda4b | |
relation.isDepartmentOfPublication.latestForDiscovery | e214da1b-9929-4ae9-b8fd-655e9bfeda4b | |
relation.isOrgUnitOfPublication | 95697b0b-8977-4af6-88d5-c29c80b5ee92 | |
relation.isOrgUnitOfPublication.latestForDiscovery | 95697b0b-8977-4af6-88d5-c29c80b5ee92 | |
unesp.author.lattes | 4083068210623663 | |
unesp.author.lattes | 3204277043366119 | |
unesp.author.lattes | 5435899068903487 | |
unesp.author.lattes | 5737933639516944 | |
unesp.author.lattes | 9734333607975413[5] | |
unesp.author.orcid | 0000-0003-4141-0455[5] | |
unesp.campus | Universidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquara | pt |
unesp.department | Fármacos e Medicamentos - FCF | pt |
Arquivos
Pacote Original
1 - 1 de 1
Carregando...
- Nome:
- ISSN1424-8247-2011-04-1450-1474.pdf
- Tamanho:
- 786.56 KB
- Formato:
- Adobe Portable Document Format