Dermatoses bolhosas auto-imunes
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FapUNIFESP (SciELO)
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Acesso aberto
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Resumo
Autoimmune bullous dermatoses are diseases in which blisters and vesicles are the primary and fundamental types of skin lesion. Their classification is based on the location of the blister: intraepidermal and subepidermal. Patients produce autoantibodies against self-specific structures of the skin detectable by immunofluorescence techniques, immunoblotting and ELISA. Recent advances in molecular and cellular biology have brought to knowledge these self-antigens, against which patients are sensitized, and which are found in epidermis or in the dermo-epidermal junction. These are low incidence, but high morbidity diseases that may be fatal. The aim of this article is to review and describe the progress of four autoimmune vesiculobullous disorders: endemic pemphigus foliaceous (wild fire), pemphigus vulgaris, bullous pemphigoid and dermatitis herpetiformis. ©2009 by Anais Brasileiros de Dermatologia.
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Allergy and immunology Bullous pemphigoid Dermatitis herpetiformis Pemphigus Skin diseases vesiculobullous antibiotic agent antigen antiparasitic agent autoantibody azathioprine chloroquine cyclophosphamide cyclosporin dapsone immunoglobulin methotrexate methylprednisolone mycophenolic acid 2 morpholinoethyl ester nicotinamide prednisone riboflavin rituximab sulfone tetracycline bacterial infection blister bullous pemphigoid chill clinical classification clinical feature dermatitis herpetiformis diet therapy drug dose reduction endemic disease enzyme linked immunosorbent assay epidermis fever gluten free diet headache histopathology human hypotension immunoblotting immunofluorescence incidence knowledge morbidity nausea pathogenesis pemphigus foliaceus pemphigus vulgaris plasmapheresis pruritus review skin defect skin sensitization strongyle infection treatment duration treatment response urticaria Autoantibodies Autoantigens Autoimmune Diseases Dermatitis Herpetiformis Enzyme-Linked Immunosorbent Assay Fluorescent Antibody Technique Humans Immunoblotting Pemphigoid, Bullous Skin Diseases, Vesiculobullous
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Português
Citação
Anais Brasileiros de Dermatologia, v. 84, n. 2, p. 111-122, 2009.
