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A duplicated nitrotienyl derivative with antimycobacterial activity: synthesis, X-ray crystallography, biological and mutagenic activity tests

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dc.contributor.authorRando, D. G.
dc.contributor.authorDoriguetto, A. C.
dc.contributor.authorde Paula da Silva, C. H. Tomich
dc.contributor.authorEllena, J.
dc.contributor.authorSato, D. N.
dc.contributor.authorLeite, Clarice Queico Fujimura [UNESP]
dc.contributor.authorVaranda, Eliana Aparecida [UNESP]
dc.contributor.authorFerreira, E. I.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de Alfenas (UNIFAL)
dc.contributor.institutionInstituto Adolfo Lutz (IAL)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:24:23Z
dc.date.available2014-05-20T13:24:23Z
dc.date.issued2006-10-01
dc.description.abstractA duplicated nitrotienyl derivative was obtained as a by-product from the synthesis of a proposed molecular hybrid of a nitrotienyl derivative and isoniazid with an expected dual antimycobacteria mechanism. The structure was shown to be the 5,5'-dinitro-2(2,3-diaza-4-(2'-tienyl)buta-1,3-dienyl)tiophene by X-ray crystallography. The minimal inhibitory concentration (MIC) determination of this compound proved to be promising against Mycobacterium pathogenic strains such as M. avium and M. kansasei, although it had a high level of mutagenicity, as observed in mutagenic activity tests. (c) 2006 Elsevier Masson SAS. All rights reserved.en
dc.description.affiliationUniv São Paulo, Fac Ciências Farmaceut, BR-05508900 São Paulo, Brazil
dc.description.affiliationUniv Fed Alfenas, UNIFALMG, BR-37130903 Alfenas, MG, Brazil
dc.description.affiliationUniv São Paulo, Fac Ciências Farmaceut, BR-14040903 Ribeirao Preto, Brazil
dc.description.affiliationUniv São Paulo, Inst Fis Sao Carlos, FFI, Grp Cristalografia, BR-13560970 Sao Carlos, SP, Brazil
dc.description.affiliationInst Adolfo Lutz Registro, BR-14085410 Ribeirao Preto, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Ciências Farmaceut, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciências Farmaceut, BR-14801902 Araraquara, SP, Brazil
dc.format.extent1196-1200
dc.identifierhttp://dx.doi.org/10.1016/j.ejmech.2006.04.009
dc.identifier.citationEuropean Journal of Medicinal Chemistry. Paris: Elsevier France-editions Scientifiques Medicales Elsevier, v. 41, n. 10, p. 1196-1200, 2006.
dc.identifier.doi10.1016/j.ejmech.2006.04.009
dc.identifier.issn0223-5234
dc.identifier.lattes2114570774349859
dc.identifier.lattes7501930236496670
dc.identifier.urihttp://hdl.handle.net/11449/7536
dc.identifier.wosWOS:000241909800009
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofEuropean Journal of Medicinal Chemistry
dc.relation.ispartofjcr4.816
dc.relation.ispartofsjr1,266
dc.rights.accessRightsAcesso restritopt
dc.sourceWeb of Science
dc.subjectnitrotienyl derivativept
dc.subjectpotential antimycobacterial agentpt
dc.subjectx-ray structure determinationpt
dc.subjectantimycobacterial activitypt
dc.subjectmutagenicitypt
dc.titleA duplicated nitrotienyl derivative with antimycobacterial activity: synthesis, X-ray crystallography, biological and mutagenic activity testsen
dc.typeArtigopt
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
relation.isDepartmentOfPublication5004bcab-94af-4939-b980-091ae9d0a19e
relation.isDepartmentOfPublication.latestForDiscovery5004bcab-94af-4939-b980-091ae9d0a19e
relation.isOrgUnitOfPublication95697b0b-8977-4af6-88d5-c29c80b5ee92
relation.isOrgUnitOfPublication.latestForDiscovery95697b0b-8977-4af6-88d5-c29c80b5ee92
unesp.author.lattes2114570774349859
unesp.author.lattes7501930236496670
unesp.author.orcid0000-0002-0676-3098[4]
unesp.author.orcid0000-0002-2726-1265[2]
unesp.author.orcid0000-0002-6586-5107[1]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentCiências Biológicas - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas