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Toxic effects of alcohol intake on prostate of rats

dc.contributor.authorNovelli, ELB
dc.contributor.authorRodrigues, N. L.
dc.contributor.authorSantos, CXC
dc.contributor.authorMartinez, F. E.
dc.contributor.authorNovelli, JLVB
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:21:40Z
dc.date.available2014-05-20T15:21:40Z
dc.date.issued1997-04-01
dc.description.abstractBACKGROUND. The present report was carried out to determine whether alcohol intake could induce prostate lesions.METHODS. We tested male rats for 300 days. Animals were divided into three groups: controls received only tap water as liquid diet; the chronic alcohol intake group received only ethanol solution in semivoluntary research; and the withdrawal group received the same treatment as chronic alcohol intake until 240 days, after which they reverted to drinking water.RESULTS. Chronic alcohol intake increased lipoperoxide concentrations and acid phosphatase activities. Cu-Zn superoxide dismutase (SOD) was decreased at 60 days, but approached controls values at 300 days following treatment. The serum increased alkaline phosphatase, and alanine transaminase activities reflected the chronic toxic effect of ethanol.CONCLUSIONS. Since SOD activity was unable to scavenge superoxide radical and lipoperoxide formation, we can conclude that superoxide is an important intermediate in prostate damage of chronic alcohol intake. (C) 1997 Wiley-Liss, Inc.en
dc.description.affiliationUNIV ESTADUAL PAULISTA,INST BIOCIENCIAS,DEPT ANAT,BOTUCATU,SP,BRAZIL
dc.description.affiliationUNIV ESTADUAL PAULISTA,FAC MED,BOTUCATU,SP,BRAZIL
dc.description.affiliationUnespUNIV ESTADUAL PAULISTA,INST BIOCIENCIAS,DEPT ANAT,BOTUCATU,SP,BRAZIL
dc.description.affiliationUnespUNIV ESTADUAL PAULISTA,FAC MED,BOTUCATU,SP,BRAZIL
dc.format.extent37-41
dc.identifierhttp://dx.doi.org/10.1002/(SICI)1097-0045(19970401)31:1<37
dc.identifier.citationProstate. New York: Wiley-liss, v. 31, n. 1, p. 37-41, 1997.
dc.identifier.doi10.1002/(SICI)1097-0045(19970401)31:1<37
dc.identifier.issn0270-4137
dc.identifier.lattes1739564105219382
dc.identifier.urihttp://hdl.handle.net/11449/32790
dc.identifier.wosWOS:A1997WT87500006
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofProstate
dc.relation.ispartofjcr3.347
dc.relation.ispartofsjr1,440
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectchronic alcohol intakept
dc.subjectsuperoxide radicalpt
dc.subjectprostatept
dc.subjectratspt
dc.titleToxic effects of alcohol intake on prostate of ratsen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell
dspace.entity.typePublication
unesp.author.lattes1739564105219382
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.departmentAnatomia - IBBpt

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