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Alzheimer's disease: Related targets, synthesis of available drugs, bioac-tive compounds under development and promising results obtained from multi-target approaches

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dc.contributor.authorPirolla, Natália F. F. [UNESP]
dc.contributor.authorBatista, Victor S. [UNESP]
dc.contributor.authorViegas, Flávia Pereira Dias
dc.contributor.authorGontijo, Vanessa Silva
dc.contributor.authorMcCarthy, Caitlin R. [UNESP]
dc.contributor.authorViegas, Claudio
dc.contributor.authorNascimento-Júnior, Nailton M. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionFederal University of Alfenas
dc.contributor.institutionUniversity of Victo-ria
dc.date.accessioned2021-06-25T10:57:56Z
dc.date.available2021-06-25T10:57:56Z
dc.date.issued2021-01-01
dc.description.abstractWe describe herein the therapeutic targets involved in Alzheimer’s disease as well as the available drugs and their synthetic routes. Bioactive compounds under development are also exploited to illustrate some recent research advances on the medicinal chemistry of Alzheimer’s disease, including structure-activity relationships for some targets. The importance of multi-target approaches, including some examples from our research projects, guides new perspectives in search of more effective drug candidates. This review comprises the period between 2001 and early 2020.en
dc.description.affiliationLaboratory of Medicinal Chemistry Organic Synthesis and Molecular Modelling (LaQMedSOMM) Institute of Chem-istry Department of Biochemistry and Organic Chemistry São Paulo State University-UNESP, Rua Professor Francisco Degni, 55, Jardim Quitandinha
dc.description.affiliationLaboratory of Research on Medicinal Chemistry (PeQuiM) Institute of Chemistry Federal University of Alfenas
dc.description.affiliationUniversity of Victo-ria, 3800 Finnerty Road
dc.description.affiliationUnespLaboratory of Medicinal Chemistry Organic Synthesis and Molecular Modelling (LaQMedSOMM) Institute of Chem-istry Department of Biochemistry and Organic Chemistry São Paulo State University-UNESP, Rua Professor Francisco Degni, 55, Jardim Quitandinha
dc.description.sponsorshipCODE
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.description.sponsorshipIdCODE: 001
dc.description.sponsorshipIdCAPES: 001
dc.description.sponsorshipIdFAPESP: 2018/00187-7
dc.description.sponsorshipIdCNPq: 310082/2016-1
dc.description.sponsorshipIdCNPq: 400271/2014-1
dc.description.sponsorshipIdCNPq: 454088/2014-0
dc.description.sponsorshipIdFAPEMIG: APQ-00241-15
dc.format.extent505-538
dc.identifierhttp://dx.doi.org/10.2174/1389450121999200819144544
dc.identifier.citationCurrent Drug Targets, v. 22, n. 5, p. 505-538, 2021.
dc.identifier.doi10.2174/1389450121999200819144544
dc.identifier.issn1873-5592
dc.identifier.issn1389-4501
dc.identifier.scopus2-s2.0-85104194121
dc.identifier.urihttp://hdl.handle.net/11449/207603
dc.language.isoeng
dc.relation.ispartofCurrent Drug Targets
dc.sourceScopus
dc.subjectAcetylcholinesterase
dc.subjectAlzheimer’s disease
dc.subjectMulti-target-directed ligands
dc.subjectNicotinic acetylcholine receptors
dc.subjectStructure-activity relationship
dc.subjectSynthetic routes
dc.titleAlzheimer's disease: Related targets, synthesis of available drugs, bioac-tive compounds under development and promising results obtained from multi-target approachesen
dc.typeArtigopt
dspace.entity.typePublication
relation.isOrgUnitOfPublicationbc74a1ce-4c4c-4dad-8378-83962d76c4fd
relation.isOrgUnitOfPublication.latestForDiscoverybc74a1ce-4c4c-4dad-8378-83962d76c4fd
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.departmentBioquímica e Tecnologia - IQpt

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Araraquara - IQAR - Instituto de Química