BOOSTING FLUORIDE-TOOTHPASTES WITH NON-FLUORIDE AGENTS FOR CARIES CONTROL
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The widespread use of toothpastes and the limited effect of fluoride (F) on caries control have stimulated the search for agents to enhance the anticaries effect of F-containing toothpastes. The association of F and different compounds, especially calcium/phosphate-based technologies, has been extensively studied as intraoral calcium and phosphate ions play a key role on the dynamics of tooth demineralization-remineralization. Technologies include the use of organic calcium/phosphate salts, inorganic cyclophosphates, nano-hydroxyapatite, and polyols. Although promising, the predominant in vitro design of the studies emphasizes the need for clinical trials to attest the efficacy and safety of F-toothpastes associated with these technologies.
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Boosting fluoride-toothpastes, Calcium/phosphate-based technologies, Caries control, Cyclophosphates, Nano-hydroxyapatite, Non-fluoride agents, Polyols
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Fluoride, v. 56, n. 4, p. 291-294, 2023.
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