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Immunolabelling of Acetylated Histones 3 and 4 and Histone Deacetylases 1, 2 and 6 in Canine Soft Tissue Sarcomas

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dc.contributor.authorSena, Bruna V.
dc.contributor.authorHorta, Rodrigo S.
dc.contributor.authorSenhorello, Igor L.S.
dc.contributor.authorMatiz, Oscar R.S.
dc.contributor.authorCanavari, Isabela C. [UNESP]
dc.contributor.authorSouza, Larissa M.
dc.contributor.authorFerreira, Marília G.P.A.
dc.contributor.authorSueiro, Felipe A.R.
dc.contributor.authorCosta, Mirela T. [UNESP]
dc.contributor.authorNardi, Andrigo B. de[UNESP]
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionUniversidade Vila Velha
dc.contributor.institutionLife – Oncologia Veterinária
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionAutonomous Veterinarian
dc.contributor.institutionHU-Univasf
dc.contributor.institutionVETPAT Pathology and Molecular Biology Laboratory
dc.date.accessioned2023-03-01T19:51:23Z
dc.date.available2023-03-01T19:51:23Z
dc.date.issued2022-05-01
dc.description.abstractThe objective of this study was to investigate the immunolabelling of acetylated histones and histone desacetylase (HDAC) enzymes in canine soft tissue sarcomas (STSs) and to correlate them with histological and clinical features in order to identify possible prognostic and therapeutic targets in these neoplasms. Fifteen canine STS samples were evaluated and were submitted to immunohistochemistry for acetylated histones 3 (H3) and 4 (H4) and deacetylating enzymes (HDAC1, HDAC2 and HDAC6). Intense immunolabelling of H4 was seen in comparison with H3. A strong positive correlation was observed between the H3 intensity score and the number of mitotic figures (P = 0.004, r = 0.7). Intense immunolabelling of HDAC1 was found in comparison to the expression of HDAC2 and HDAC6 in the evaluated STSs. This finding suggests that HDAC1 may be a potential target for HDAC inhibitors in STSs in dogs.en
dc.description.affiliationDepartment of Veterinary Medicine and Surgery Veterinay School Universidade Federal de Minas Gerais, MG
dc.description.affiliationDepartment of Veterinary Medicine Universidade Vila Velha, ES
dc.description.affiliationAutonomous Veterinarian Life – Oncologia Veterinária
dc.description.affiliationDepartment of Clinical and Veterinary Surgery College of Agricultural and Veterinary Sciences Universidade Estadual Paulista Júlio de Mesquita Filho UNESP, SP
dc.description.affiliationAutonomous Veterinarian, ES
dc.description.affiliationVeterinary Hospital Universidade Federal do Vale do São Francisco HU-Univasf, PE
dc.description.affiliationVETPAT Pathology and Molecular Biology Laboratory, SP
dc.description.affiliationUnespDepartment of Clinical and Veterinary Surgery College of Agricultural and Veterinary Sciences Universidade Estadual Paulista Júlio de Mesquita Filho UNESP, SP
dc.format.extent51-58
dc.identifierhttp://dx.doi.org/10.1016/j.jcpa.2022.03.001
dc.identifier.citationJournal of Comparative Pathology, v. 193, p. 51-58.
dc.identifier.doi10.1016/j.jcpa.2022.03.001
dc.identifier.issn1532-3129
dc.identifier.issn0021-9975
dc.identifier.scopus2-s2.0-85128184230
dc.identifier.urihttp://hdl.handle.net/11449/239877
dc.language.isoeng
dc.relation.ispartofJournal of Comparative Pathology
dc.sourceScopus
dc.subjectcanine
dc.subjectepigenetic
dc.subjecthistones
dc.subjectmesenchymal neoplasia
dc.titleImmunolabelling of Acetylated Histones 3 and 4 and Histone Deacetylases 1, 2 and 6 in Canine Soft Tissue Sarcomasen
dc.typeArtigopt
dspace.entity.typePublication
relation.isOrgUnitOfPublication3d807254-e442-45e5-a80b-0f6bf3a26e48
relation.isOrgUnitOfPublication.latestForDiscovery3d807254-e442-45e5-a80b-0f6bf3a26e48
unesp.author.orcid0000-0002-2396-7412[1]
unesp.author.orcid0000-0002-9885-4498[2]
unesp.author.orcid0000-0003-4569-781X[5]
unesp.author.orcid0000-0001-5329-3466[7]
unesp.author.orcid0000-0001-8524-479X[8]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt

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Jaboticabal - FCAV - Faculdade de Ciências Agrárias e Veterinárias