Publicação:
Antiestrogen therapies affect tissue homeostasis of the gerbil (Meriones unguiculatus) female prostate and ovaries

dc.contributor.authorSantos, Fernanda C. A.
dc.contributor.authorCustodio, Ana M. G.
dc.contributor.authorCampos, Silvana G. P. [UNESP]
dc.contributor.authorVilamaior, Patricia S. L.
dc.contributor.authorGoes, Rejane M. [UNESP]
dc.contributor.authorTaboga, Sebastiao R. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionRio Preto Univ Ctr UNIRP
dc.date.accessioned2014-05-20T14:00:52Z
dc.date.available2014-05-20T14:00:52Z
dc.date.issued2008-10-01
dc.description.abstractThe present work aims to evaluate the response of the adult gerbil female prostate (paraurethral glands) and ovaries to short-term exposure to antiestrogenic agents, consisting of daily oral doses of letrozole (1 mg kg(-1) day(-1)) or intradermal doses of tamoxifen (1 mg/kg) every other day for 21 days. The serum levels of testosterone and estradiol were monitored, and the prostates and ovaries collected for structural, ultrastructural, and immunocytochemical analyses. The letrozole treatment resulted in increases of serum testosterone levels and secretory activity as well as in glandular hyperplasia and dysplastic growth, simulating the effects caused by the exogenous androgens. The effects caused by tamoxifen indicate that this endocrine agent acted as an estrogenic agonist on the prostate, causing glandular hypertrophy, secretory activity decrease, and the development of prostatic lesions. Therefore, it is possible to conclude that the letrozole and tamoxifen therapies result in a series of complex effects that endanger the physiology of hormone-dependent organs, including the female prostate and ovaries. The hormonal imbalance caused by administration of these drugs resulted in considerable changes in prostatic morphology, in a manner very similar to what occurs during the development of prostatic lesions in aged postmenopausal women. Thus, these therapies must be chosen carefully since long-term treatments can result in female prostate dysplasic lesions.en
dc.description.affiliationUNESP, IBILCE, Dept Biol, Lab Microscopy & Microanal, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Inst Biol, Dept Cell Biol, BR-13084864 Campinas, SP, Brazil
dc.description.affiliationRio Preto Univ Ctr UNIRP, Biol Sci & Vet Med Sch, BR-15025400 Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUnespUNESP, IBILCE, Dept Biol, Lab Microscopy & Microanal, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdCNPq: 301111/05-7
dc.description.sponsorshipIdFAPESP: 02/12942-6
dc.format.extent674-685
dc.identifierhttp://dx.doi.org/10.1095/biolreprod.108.068759
dc.identifier.citationBiology of Reproduction. Madison: Soc Study Reproduction, v. 79, n. 4, p. 674-685, 2008.
dc.identifier.doi10.1095/biolreprod.108.068759
dc.identifier.issn0006-3363
dc.identifier.lattes7066358123790434
dc.identifier.lattes0947193347312157
dc.identifier.orcid0000-0002-0970-4288
dc.identifier.orcid0000-0001-9559-5497
dc.identifier.orcid0000-0002-3622-460X
dc.identifier.urihttp://hdl.handle.net/11449/21506
dc.identifier.wosWOS:000259305300012
dc.language.isoeng
dc.publisherSoc Study Reproduction
dc.relation.ispartofBiology of Reproduction
dc.relation.ispartofjcr3.184
dc.relation.ispartofsjr1,446
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectandrogensen
dc.subjectestradiolen
dc.subjectfemale prostateen
dc.subjectfemale reproductive tracten
dc.subjectletrozoleen
dc.subjectmorphologyen
dc.subjectovaryen
dc.subjectprostateen
dc.subjecttamoxifenen
dc.titleAntiestrogen therapies affect tissue homeostasis of the gerbil (Meriones unguiculatus) female prostate and ovariesen
dc.typeArtigo
dcterms.licensehttp://www.biolreprod.org/site/IforA/editorialpolicies.xhtml
dcterms.rightsHolderSoc Study Reproduction
dspace.entity.typePublication
unesp.author.lattes7066358123790434[4]
unesp.author.lattes0947193347312157[5]
unesp.author.orcid0000-0001-9559-5497[4]
unesp.author.orcid0000-0002-0970-4288[6]
unesp.author.orcid0000-0002-3622-460X[5]

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