Efeitos cardiovasculares de diferentes FiO2 em coelhos submetidos ao pneumoperitônio, em cefalodeclive

Abstract

The effects of several inspired oxygen fractions (FiO2) on the cardiovascular parameters were evaluated in rabbits undergoing pneumoperitoneum under head-down tilt position (Trendelenburg position at 30°). The animals were premedicated with acepromazine (0.5 mg/kg) and, thereafter underwent general anesthesia with propofol (10 mg//kg), followed by continuous infusion of (1.2 mg/kg/min) and rocuronium (0.6 mg/kg), followed by continuous infusion of (0.6 mg/kg/h). The patients were distributed into three groups according to the FiO2 regimen during general anesthesia: G40 (FiO2 = 0.4), G60 (FiO2 = 0.6) and G100 (FiO2 = 1.0). The variables cardiac rate, systolic, media and diastolic pressure and venous central pressure were evaluated. The first data sampling was carried out one hour after anesthesia induction (M0). and every 20-minute intervals for 100 minutes (M20 to M100). The animals were maintained in time controlled ventilation. Additionally, PEEP (2 cmH2O) was performed in M80 and M100. Numeric data were submitted to Profile Analysis (p<0.05). Results showed that FiO2 does not impair hemodynamic parameters.