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Acute lymphoblastic leukemia: Primary bone manifestation with hypercalcemia in a child

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dc.contributor.authorOliveira, Cristiano C. [UNESP]
dc.contributor.authorKucko, Luan [UNESP]
dc.contributor.authorHirama, Eric J. [UNESP]
dc.contributor.authorGuerra, Helena M. [UNESP]
dc.contributor.authorTerra, Simone A. [UNESP]
dc.contributor.authorSantiago, Lied M. [UNESP]
dc.contributor.authorSegredo, Manuella P. [UNESP]
dc.contributor.authorNiero-Melo, Ligia [UNESP]
dc.contributor.authorDomingues, Maria Aparecida C. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T16:46:28Z
dc.date.available2018-12-11T16:46:28Z
dc.date.issued2017-01-01
dc.description.abstractPrimary bone manifestation associated with hypercalcemia is an infrequent presentation of acute lymphoblastic leukemia (ALL) in children. An 8-year-old girl was admitted with bone and abdomen pain, vomiting, fever, headache, anemia, elevated serum calcium and normal parathyroid hormone levels. Bone radiographs: osteolytic lesions. Bone marrow biopsy showed an infiltration by ALL with immunohistochemical positivity for CD45, CD20, CD79a, TdT and CD10, clinically characterized by hypercalcemia, multifocal osteolytic lesions and single cytopenia. Bone marrow biopsy was a relevant aid in establishing the diagnosis of multifocal osteolytic lesions, associated with hypercalcemia.en
dc.description.affiliationUniversidade Estadual Paulista (Unesp)
dc.description.affiliationUnespUniversidade Estadual Paulista (Unesp)
dc.format.extent61-64
dc.identifierhttp://dx.doi.org/10.5935/1676-2444.20170010
dc.identifier.citationJornal Brasileiro de Patologia e Medicina Laboratorial, v. 53, n. 1, p. 61-64, 2017.
dc.identifier.doi10.5935/1676-2444.20170010
dc.identifier.fileS1676-24442017000100061.pdf
dc.identifier.issn1678-4774
dc.identifier.issn1676-2444
dc.identifier.scieloS1676-24442017000100061
dc.identifier.scopus2-s2.0-85015962367
dc.identifier.urihttp://hdl.handle.net/11449/169566
dc.language.isoeng
dc.relation.ispartofJornal Brasileiro de Patologia e Medicina Laboratorial
dc.relation.ispartofsjr0,143
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectBone marrow
dc.subjectHypercalcemia
dc.subjectPrecursor B-cell lymphoblastic leukemia-lymphoma
dc.titleAcute lymphoblastic leukemia: Primary bone manifestation with hypercalcemia in a childen
dc.typeArtigo
dspace.entity.typePublication

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